CCR5

CCR5
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2L87, 2RLL, 2RRS, 2MZX, 4MBS
Identifikatori
Aliasi	CCR5
Vanjski ID-jevi	OMIM: 601373 MGI: 107182 HomoloGene: 37325 GeneCards: CCR5
Lokacija gena (čovjek) Hrom. Hromosom 3 (čovjek)[1] Bend 3p21.31 Početak 46,370,946 bp[1] Kraj 46,376,206 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9 F4|9 75.05 cM Početak 123,921,580 bp[2] Kraj 123,947,736 bp[2]
Ontologija gena Molekularna funkcija • G protein-coupled receptor activity • coreceptor activity • chemokine (C-C motif) ligand 5 binding • virus receptor activity • signal transducer activity • GO:0001948, GO:0016582 vezivanje za proteine • chemokine receptor activity • C-C chemokine receptor activity • actin binding • phosphatidylinositol phospholipase C activity • C-C chemokine binding • chemokine binding Ćelijska komponenta • citoplazma • integral component of membrane • endozom • membrana • ćelijska membrana • integral component of plasma membrane • external side of plasma membrane • cell surface Biološki proces • G protein-coupled receptor signaling pathway • signaling • response to cholesterol • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • dendritic cell chemotaxis • MAPK cascade • Hemotaksija • cellular defense response • cell surface receptor signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • inflammatory response • cellular response to lipopolysaccharide • calcium ion transport • calcium-mediated signaling • GO:0072468 Transdukcija signala • fusion of virus membrane with host plasma membrane • chemokine-mediated signaling pathway • GO:0022415 viral process • defense response • negative regulation of macrophage apoptotic process • cytokine-mediated signaling pathway • cell chemotaxis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1234	12774
Ensembl	ENSG00000160791	ENSMUSG00000079227
UniProt	P51681	P51682
RefSeq (mRNK)	NM_001100168 NM_000579 NM_001394783	NM_009917
RefSeq (bjelančevina)	NP_000570 NP_001093638	NP_034047
Lokacija (UCSC)	Chr 3: 46.37 – 46.38 Mb	Chr 9: 123.92 – 123.95 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

C-C hemokinski receptor tip 5, znan i kao CCR5 ili CD195, je protein na površini leukocita, uključen imunski sistem, kao receptor za hemokine.^[5]

Kod ljudi, određene populacije naslijedile su mutaciju Delta 32, što je rezultiralo delecijom dijela gena CCR5. Homozigot ni nositelji ove mutacije otporni su na M-tropske sojeve HIV-1 infekcije.^{[6][7][8][9][10][11]}

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000160791 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000079227 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Jiao X, Nawab O, Patel T, Kossenkov AV, Halama N, Jaeger D, Pestell RG (Oct 2019). "Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology". Cancer Research. 79 (19): 4801–4807. doi:10.1158/0008-5472.CAN-19-1167. PMC 6810651. PMID 31292161.
6. ^ de Silva E, Stumpf MP (Dec 2004). "HIV and the CCR5-Delta32 resistance allele". FEMS Microbiology Letters. 241 (1): 1–12. doi:10.1016/j.femsle.2004.09.040. PMID 15556703.
7. ^ Hütter G, Nowak D, Mossner M, Ganepola S, Müssig A, Allers K, Schneider T, Hofmann J, Kücherer C, Blau O, Blau IW, Hofmann WK, Thiel E (Feb 2009). "Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation". The New England Journal of Medicine. 360 (7): 692–8. doi:10.1056/NEJMoa0802905. PMID 19213682.
8. ^ Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, Schneider T (Mar 2011). "Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation". Blood. 117 (10): 2791–9. doi:10.1182/blood-2010-09-309591. PMID 21148083.
9. ^ Zhen A, Kitchen S (Jan 2014). "Stem-cell-based gene therapy for HIV infection". Viruses. 6 (1): 1–12. doi:10.3390/v6010001. PMC 3917429. PMID 24368413.
10. ^ Kay MA, Walker BD (Mar 2014). "Engineering cellular resistance to HIV". The New England Journal of Medicine. 370 (10): 968–9. doi:10.1056/NEJMe1400593. PMID 24597871.
11. ^ Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. (Mar 2014). "Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV". The New England Journal of Medicine. 370 (10): 901–10. doi:10.1056/NEJMoa1300662. PMC 4084652. PMID 24597865.