DRD2

DRD2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	6CM4
Dynodwyr
Cyfenwau	DRD2, D2DR, D2R, dopamine receptor D2
Dynodwyr allanol	OMIM: 126450 HomoloGene: 22561 GeneCards: DRD2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • potassium channel regulator activity; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • identical protein binding; • dopamine neurotransmitter receptor activity; • G protein-coupled receptor activity; • GO:0001948, GO:0016582 protein binding; • signal transducer activity; • adrenergic receptor activity; • dopamine binding; • signaling receptor binding; • ionotropic glutamate receptor binding; • protein heterodimerization activity;
Cydrannau o'r gell	• GO:0016023 cytoplasmic vesicle; • sperm flagellum; • endocytic vesicle; • acrosomal vesicle; • dendritic spine; • synaptic vesicle membrane; • perikaryon; • Cellbilen; • dendrite; • ciliary membrane; • axon terminus; • integral component of membrane; • GO:0097483, GO:0097481 postsynaptic density; • bilen; • lateral plasma membrane; • axon; • intracellular anatomical structure; • non-motile cilium; • integral component of plasma membrane; • dopaminergic synapse; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
Prosesau biolegol	• negative regulation of cell population proliferation; • temperature homeostasis; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • adenohypophysis development; • circadian regulation of gene expression; • response to toxic substance; • regulation of dopamine secretion; • adwaith i gocên; • response to amphetamine; • sensory perception of smell; • locomotory behavior; • positive regulation of urine volume; • response to ethanol; • axonogenesis; • response to inactivity; • phospholipase C-activating dopamine receptor signaling pathway; • modulation of chemical synaptic transmission; • grooming behavior; • negative regulation of protein kinase B signaling; • associative learning; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • regulation of dopamine uptake involved in synaptic transmission; • regulation of synaptic transmission, GABAergic; • positive regulation of dopamine uptake involved in synaptic transmission; • GO:0072468 signal transduction; • Wnt signaling pathway; • adult walking behavior; • branching morphogenesis of a nerve; • negative regulation of cytosolic calcium ion concentration; • negative regulation of innate immune response; • regulation of phosphoprotein phosphatase activity; • acid secretion; • feeding behavior; • positive regulation of G protein-coupled receptor signaling pathway; • response to axon injury; • striatum development; • synaptic transmission, dopaminergic; • nervous system process involved in regulation of systemic arterial blood pressure; • peristalsis; • regulation of long-term neuronal synaptic plasticity; • activation of protein kinase activity; • positive regulation of growth hormone secretion; • regulation of sodium ion transport; • forebrain development; • response to light stimulus; • orbitofrontal cortex development; • prepulse inhibition; • response to morphine; • response to iron ion; • positive regulation of ERK1 and ERK2 cascade; • long-term memory; • positive regulation of renal sodium excretion; • negative regulation of insulin secretion; • neuron-neuron synaptic transmission; • GO:0007243 intracellular signal transduction; • auditory behavior; • behavioral response to ethanol; • regulation of heart rate; • adenylate cyclase-activating adrenergic receptor signaling pathway; • positive regulation of cytokinesis; • regulation of potassium ion transport; • pigmentation; • cellular calcium ion homeostasis; • dopamine metabolic process; • response to nicotine; • regulation of MAPK cascade; • response to histamine; • negative regulation of synaptic transmission, glutamatergic; • response to hypoxia; • negative regulation of circadian sleep/wake cycle, sleep; • negative regulation of protein secretion; • synapse assembly; • regulation of locomotion involved in locomotory behavior; • dopamine receptor signaling pathway; • negative regulation of dopamine receptor signaling pathway; • startle response; • positive regulation of receptor internalization; • GO:0034613 protein localization; • arachidonic acid secretion; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • G protein-coupled receptor internalization; • positive regulation of multicellular organism growth; • positive regulation of long-term synaptic potentiation; • negative regulation of dopamine secretion; • adult behavior; • cerebral cortex GABAergic interneuron migration; • regulation of synapse structural plasticity; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • visual learning; • negative regulation of cell migration; • behavioral response to cocaine; • positive regulation of neuroblast proliferation; • negative regulation of blood pressure; • release of sequestered calcium ion into cytosol; • negative regulation of voltage-gated calcium channel activity; • G protein-coupled receptor signaling pathway; • negative regulation of adenylate cyclase activity; • excitatory postsynaptic potential; • GO:0033128 negative regulation of protein phosphorylation; • autophagy; • positive regulation of neurogenesis; • negative regulation of cell death; • drinking behavior; • adrenergic receptor signaling pathway; • regulation of neurotransmitter uptake; • postsynaptic modulation of chemical synaptic transmission; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologau
	1813
	n/a
	ENSG00000149295
	n/a
	P14416
	n/a
	NM_016574; NM_000795
	n/a
	NP_000786; NP_057658; NP_000786.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DRD2 yw DRD2 a elwir hefyd yn Dopamine receptor D2, isoform CRA_c (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.2.^[2]

[1] "Human PubMed Reference:".

[2] DRD2 - Cronfa NCBI

[1]

[2]

DRD2

From Wikipedia, the free encyclopedia · View on Wikipedia