EGF

EGF
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1IVO, 1JL9, 1NQL, 1P9J, 2KV4, 3NJP
Identifikatori
Aliasi	EGF
Vanjski ID-jevi	OMIM: 131530 MGI: 95290 HomoloGene: 1483 GeneCards: EGF
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q25 Početak 109,912,883 bp[1] Kraj 110,013,766 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3 G3|3 58.5 cM Početak 129,471,214 bp[2] Kraj 129,548,965 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • calcium ion binding • transmembrane receptor protein tyrosine kinase activator activity • epidermal growth factor receptor binding • Wnt-protein binding • GO:0001948, GO:0016582 vezivanje za proteine • growth factor activity • Wnt-activated receptor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Ćelijska komponenta • integral component of membrane • membrana • receptor complex • extracellular region • lysosomal membrane • Egzosom • platelet alpha granule lumen • Vanćelijsko • clathrin-coated vesicle membrane • ćelijska membrana Biološki proces • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of MAP kinase activity • epidermal growth factor receptor signaling pathway • regulation of protein localization to cell surface • ERK1 and ERK2 cascade • platelet degranulation • regulation of calcium ion import • mammary gland alveolus development • MAPK cascade • Replikacija DNK • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of secretion • positive regulation of hyaluronan biosynthetic process • positive regulation of peptidyl-threonine phosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • Angiogeneza • Wnt signaling pathway involved in dorsal/ventral axis specification • positive regulation of cell population proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of cerebellar granule cell precursor proliferation • canonical Wnt signaling pathway • negative regulation of cholesterol efflux • peptidyl-tyrosine phosphorylation • positive regulation of DNA binding • positive regulation of phosphorylation • positive regulation of mitotic nuclear division • branching morphogenesis of an epithelial tube • GO:0072468 Transdukcija signala • regulation of peptidyl-tyrosine phosphorylation • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • positive regulation of protein tyrosine kinase activity • activation of transmembrane receptor protein tyrosine kinase activity • regulation of cell motility • positive regulation of receptor internalization • positive regulation of epidermal growth factor-activated receptor activity • membrane organization • negative regulation of ERBB signaling pathway • embryonic retina morphogenesis in camera-type eye • GO:1901313 positive regulation of gene expression • positive regulation of cell migration • positive regulation of protein kinase B signaling • negative regulation of Notch signaling pathway • regulation of receptor signaling pathway via JAK-STAT • positive regulation of canonical Wnt signaling pathway • positive regulation of protein localization to early endosome Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1950	13645
Ensembl	ENSG00000138798	ENSMUSG00000028017
UniProt	P01133	P01132
RefSeq (mRNK)	NM_001178130 NM_001178131 NM_001963 NM_001357021	NM_010113 NM_001310737 NM_001329594
RefSeq (bjelančevina)	NP_001171601 NP_001171602 NP_001954 NP_001343950	NP_001297666 NP_001316523 NP_034243
Lokacija (UCSC)	Chr 4: 109.91 – 110.01 Mb	Chr 3: 129.47 – 129.55 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Epidermni faktor rasta (EGF) jest protein koji je kod ljudi kodiran genom sa hromosoma 4. Stimulira ćelijski rast i diferencijaciju vezivanjem za svoj receptor, EGFR^[5] i ima 53 aminokiselinska ostatka i tri unutarmolekulske disulfidne veze.^[6]

EGF je prvobitno opisan kao izlučeni peptid koji se nalazi u submaksilskim žlijezdama miševa i u ljudskom urinu. EGF je od tada pronađen u mnogim ljudskim tkivima, uključujući submandibulsku žlijezdu (submaksillska žlijezda),^[7] i paratidnim žlijezdama.^[7] U početku, ljudski EGF bio poznat kao urogastron.^[8]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000138798 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000028017 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Harris RC, Chung E, Coffey RJ (mart 2003). "EGF receptor ligands". Experimental Cell Research. 284 (1): 2–13. doi:10.1016/S0014-4827(02)00105-2. PMID 12648462.
6. ^ Carpenter G, Cohen S (maj 1990). "Epidermal growth factor". The Journal of Biological Chemistry. 265 (14): 7709–12. doi:10.1016/S0021-9258(19)38983-5. PMID 2186024. Arhivirano s originala, 5. 11. 2008. Pristupljeno 28. 10. 2021.
7. ^ ^{a b} Greška kod citiranja: Nevaljana oznaka <ref>; nije naveden tekst za reference s imenom Venturi2009
8. ^ Hollenberg MD, Gregory H (maj 1980). "Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives". Molecular Pharmacology. 17 (3): 314–20. PMID 6248761.