Back خلية كيراتينية Arabic Keratinocit BS Queratinòcit Catalan Keratinocyt Czech Keratinozyt German Κερατινοκύτταρα Greek Queratinocito Spanish کراتینوسیت Persian Kératinocyte French Queratinocito Galician

Keratinocyte

Micrograph of keratinocytes, basal cells and melanocytes in the epidermis
Keratinocytes (stained green) in the skin of a mouse

Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells.[1] Basal cells in the basal layer (stratum basale) of the skin are sometimes referred to as basal keratinocytes.[2] Keratinocytes form a barrier against environmental damage by heat, UV radiation, water loss, pathogenic bacteria, fungi, parasites, and viruses. A number of structural proteins, enzymes, lipids, and antimicrobial peptides contribute to maintain the important barrier function of the skin. Keratinocytes differentiate from epidermal stem cells in the lower part of the epidermis and migrate towards the surface, finally becoming corneocytes and eventually being shed,[3][4][5][6] which happens every 40 to 56 days in humans.[7]

  1. ^ McGrath JA; Eady RAJ; Pope FM. (2004). "Anatomy and Organization of Human Skin". In Burns T; Breathnach S; Cox N; Griffiths C. (eds.). Rook's Textbook of Dermatology (7th ed.). Blackwell Publishing. p. 4190. doi:10.1002/9780470750520.ch3. ISBN 978-0-632-06429-8. Archived from the original on 2020-05-20. Retrieved 2010-06-01.
  2. ^ James W, Berger T, Elston D (December 2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. pp. 5–6. ISBN 978-0-7216-2921-6. Archived from the original on 2010-10-11. Retrieved 2010-06-01.
  3. ^ Cite error: The named reference Gilbert2000 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference pmid17191035-2007 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference pmid11250888-2001 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference pmid19686098-2009 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference pmid4551262-1972 was invoked but never defined (see the help page).
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