PPARGC1A

PPARGC1A
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1XB7, 3B1M, 3CS8, 3D24, 3U9Q, 3V9T, 3V9V, 4QJR, 4QK4
識別子
記号	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha, PGC-1α
外部ID	OMIM: 604517 MGI: 1342774 HomoloGene: 7485 GeneCards: PPARGC1A
遺伝子の位置 (マウス)
染色体	5番染色体 (マウス)
終点	51,725,068 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• promoter-specific chromatin binding; • 転写因子結合; • クロマチン結合; • 血漿タンパク結合; • nuclear receptor binding; • 核酸結合; • DNA結合; • sequence-specific DNA binding; • transcription coactivator activity; • alpha-tubulin binding; • transcription coregulator activity; • androgen receptor binding; • nuclear receptor coactivator activity; • RNA結合; • chromatin DNA binding; • ubiquitin protein ligase binding; • 受容体結合; • estrogen receptor binding; • peroxisome proliferator activated receptor binding;
細胞の構成要素	• 細胞質; • 細胞質基質; • cytosolic ribosome; • 細胞核; • RNAポリメラーゼII; • 尖端樹状突起; • neuronal cell body; • PML body; • 核質; • intracellular membrane-bounded organelle;
生物学的プロセス	• negative regulation of neuron apoptotic process; • response to dietary excess; • negative regulation of glycolytic process; • response to fructose; • cellular response to interleukin-6; • 周期的プロセス; • cellular response to resveratrol; • response to thyroid hormone; • cellular response to fructose stimulus; • cellular response to ionomycin; • adaptive thermogenesis; • response to ischemia; • 概日リズム; • fatty acid oxidation; • response to metformin; • cellular response to caffeine; • response to electrical stimulus involved in regulation of muscle adaptation; • temperature homeostasis; • cellular response to hypoxia; • cellular response to glucose stimulus; • positive regulation of fatty acid oxidation; • cellular response to transforming growth factor beta stimulus; • positive regulation of progesterone biosynthetic process; • regulation of transcription, DNA-templated; • cellular response to follicle-stimulating hormone stimulus; • アンドロゲン代謝プロセス; • 活性酸素への反応; • positive regulation of mitochondrial DNA metabolic process; • 消化; • response to leucine; • response to norepinephrine; • response to epinephrine; • transcription, DNA-templated; • negative regulation of mitochondrial fission; • positive regulation of transcription, DNA-templated; • positive regulation of glomerular visceral epithelial cell apoptotic process; • response to nutrient levels; • RNAスプライシング; • skeletal muscle atrophy; • 細胞呼吸; • negative regulation of signaling receptor activity; • positive regulation of gluconeogenesis; • transcription initiation from RNA polymerase II promoter; • cellular response to potassium ion; • negative regulation of neuron death; • negative regulation of protein phosphorylation; • positive regulation of cellular respiration; • mRNA processing; • タンパク質の安定化; • mitochondrion organization; • positive regulation of DNA-binding transcription factor activity; • response to electrical stimulus; • circadian regulation of gene expression; • 小脳発生; • positive regulation of ATP biosynthetic process; • regulation of NMDA receptor activity; • galactose metabolic process; • positive regulation of muscle tissue development; • regulation of circadian rhythm; • flavone metabolic process; • 脂肪組織発生; • respiratory electron transport chain; • positive regulation of cellular metabolic process; • response to muscle activity; • cellular response to nitrite; • positive regulation of smooth muscle cell proliferation; • 糖新生; • androgen receptor signaling pathway; • negative regulation of smooth muscle cell proliferation; • 低酸素症への反応; • 有機環状化合物への反応; • cellular glucose homeostasis; • cellular response to tumor necrosis factor; • cellular response to estradiol stimulus; • 老化; • negative regulation of smooth muscle cell migration; • response to activity; • positive regulation of histone acetylation; • cellular response to fatty acid; • マイトファジー; • cellular response to thyroid hormone stimulus; • response to methionine; • 餓死; • response to cold; • cellular response to oxidative stress; • 前脳発生; • cellular response to lipopolysaccharide; • positive regulation of transcription by RNA polymerase II; • positive regulation of mitochondrion organization; • 褐色脂肪細胞の分化; • protein-containing complex assembly; • energy homeostasis; • positive regulation of gene expression; • positive regulation of cold-induced thermogenesis;
	出典:Amigo / QuickGO
オルソログ
	10891
	19017
	ENSG00000109819
	ENSMUSG00000029167
	Q9UBK2
	O70343
	NM_013261; NM_001330751; NM_001330752; NM_001330753
	NM_008904
NP_001317680; NP_001317681; NP_001317682; NP_037393; NP_001341754;
	NP_001341755; NP_001341756; NP_001341757
NP_032930; NP_001389916; NP_001389917; NP_001389918; NP_001389919;
	NP_001389920
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

PPARGC1AまたはPGC-1α（peroxisome proliferator-activated receptor gamma coactivator 1-alpha）は、ヒトではPPARGC1A遺伝子にコードされるタンパク質である^[4]。PPARGC1Aはhuman accelerated regionと呼ばれる、チンパンジーとの共通祖先からの分岐以降に塩基置換率が加速しているゲノム領域（HAR20）と関係しており、そのため類人猿からヒトの分岐に重要な役割を果たした可能性がある^[5]。

PGC-1αは、ミトコンドリア生合成（英語版）のマスターレギュレーター（英語版）である^[6]^[7]^[8]。また、PGC-1αは肝臓における糖新生の主要な調節因子であり、糖新生のための遺伝子発現の増加などを担う^[9]。

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029167 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ Esterbauer H, Oberkofler H, Krempler F, Patsch W (February 2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics. 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775。
^ Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans". Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797。
^ Valero T (2014). "Mitochondrial biogenesis: pharmacological approaches". Curr. Pharm. Des. 20 (35): 5507–9. doi:10.2174/138161282035140911142118. hdl:10454/13341. PMID 24606795. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. ... This work reviews different strategies to enhance mitochondrial bioenergetics in order to ameliorate the neurodegenerative process, with an emphasis on clinical trials reports that indicate their potential. Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable effects in clinical trials.
^ Sanchis-Gomar F, García-Giménez JL, Gómez-Cabrera MC, Pallardó FV (2014). "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches". Curr. Pharm. Des. 20 (35): 5619–5633. doi:10.2174/1381612820666140306095106. PMID 24606801. Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria.
^ Dorn GW, Vega RB, Kelly DP (2015). "Mitochondrial biogenesis and dynamics in the developing and diseased heart". Genes Dev. 29 (19): 1981–91. doi:10.1101/gad.269894.115. PMC 4604339. PMID 26443844。
^ Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". Journal of Biological Chemistry. 295 (32): 11021–11041. doi:10.1074/jbc.REV120.011438. PMC 7415977. PMID 32518153。

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000029167 - Ensembl, May 2017

[2] Human PubMed Reference:

[3] Mouse PubMed Reference:

[pmid10585775-4] Esterbauer H, Oberkofler H, Krempler F, Patsch W (February 2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics. 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775。

[pmid16915236-5] Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans". Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797。

[Mitochondrial_biogenesis-6] Valero T (2014). "Mitochondrial biogenesis: pharmacological approaches". Curr. Pharm. Des. 20 (35): 5507–9. doi:10.2174/138161282035140911142118. hdl:10454/13341. PMID 24606795. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. ... This work reviews different strategies to enhance mitochondrial bioenergetics in order to ameliorate the neurodegenerative process, with an emphasis on clinical trials reports that indicate their potential. Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable effects in clinical trials.

[Mitochondrial_biogenesis_in_health_and_disease-7] Sanchis-Gomar F, García-Giménez JL, Gómez-Cabrera MC, Pallardó FV (2014). "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches". Curr. Pharm. Des. 20 (35): 5619–5633. doi:10.2174/1381612820666140306095106. PMID 24606801. Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria.

[pmid26443844-8] Dorn GW, Vega RB, Kelly DP (2015). "Mitochondrial biogenesis and dynamics in the developing and diseased heart". Genes Dev. 29 (19): 1981–91. doi:10.1101/gad.269894.115. PMC 4604339. PMID 26443844。

[pmid32518153-9] Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". Journal of Biological Chemistry. 295 (32): 11021–11041. doi:10.1074/jbc.REV120.011438. PMC 7415977. PMID 32518153。

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PPARGC1A

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