Torcetrapib

Torcetrapib

Names
Preferred IUPAC name Ethyl (2R,4S)-4-({[3,5-bis(trifluoromethyl)phenyl]methyl}(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
Identifiers
CAS Number	262352-17-0 N
3D model (JSmol)	Interactive image
ChEBI	CHEBI:49203 Y
ChEMBL	ChEMBL479527 Y
ChemSpider	140123 Y
ECHA InfoCard	100.216.319
KEGG	D06195 Y
PubChem CID	159325
UNII	4N4457MV2U Y
CompTox Dashboard (EPA)	DTXSID20180873
InChI InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1 Y Key: CMSGWTNRGKRWGS-NQIIRXRSSA-N Y InChI=1/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1 Key: CMSGWTNRGKRWGS-NQIIRXRSBY
SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)CN(C(=O)OC)[C@@H]3c2c(ccc(c2)C(F)(F)F)N(C(=O)OCC)[C@@H](C3)CC
Properties
Chemical formula	C26H25F9N2O4
Molar mass	600.473
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Torcetrapib (CP-529,414, Pfizer) was a drug being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease. Its development was halted in 2006 when phase III studies showed excessive all-cause mortality in the treatment group receiving a combination of atorvastatin (Lipitor) and torcetrapib.