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Names | |||
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Preferred IUPAC name
1,4-Dioxane | |||
Systematic IUPAC name
1,4-Dioxacyclohexane | |||
Other names
[1,4]Dioxane
p-Dioxane [6]-crown-2 Diethylene dioxide Diethylene ether Dioxane solvent | |||
Identifiers | |||
3D model (JSmol)
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102551 | |||
ChEBI | |||
ChEMBL | |||
ChemSpider | |||
DrugBank | |||
ECHA InfoCard | 100.004.239 | ||
EC Number |
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KEGG | |||
PubChem CID
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RTECS number |
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UNII | |||
UN number | 1165 | ||
CompTox Dashboard (EPA)
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Properties | |||
C4H8O2 | |||
Molar mass | 88.106 g·mol−1 | ||
Appearance | Colorless liquid[1] | ||
Odor | Mild, diethyl ether-like[1] | ||
Density | 1.033 g/mL | ||
Melting point | 11.8 °C (53.2 °F; 284.9 K) | ||
Boiling point | 101.1 °C (214.0 °F; 374.2 K) | ||
Miscible | |||
Vapor pressure | 29 mmHg (20 °C)[1] | ||
−52.16·10−6 cm3/mol | |||
Thermochemistry | |||
Std molar
entropy (S⦵298) |
196.6 J/K·mol | ||
Std enthalpy of
formation (ΔfH⦵298) |
−354 kJ/mol | ||
Std enthalpy of
combustion (ΔcH⦵298) |
−2363 kJ/mol | ||
Hazards | |||
Occupational safety and health (OHS/OSH): | |||
Main hazards
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Suspected human carcinogen[1] | ||
GHS labelling: | |||
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Danger | |||
H225, H302, H305, H315, H319, H332, H336, H351, H370, H372, H373 | |||
P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P281, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P307+P311, P308+P313, P312, P314, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, P501 | |||
NFPA 704 (fire diamond) | |||
Flash point | 12 °C (54 °F; 285 K) | ||
180 °C (356 °F; 453 K) | |||
Explosive limits | 2.0–22%[1] | ||
Lethal dose or concentration (LD, LC): | |||
LD50 (median dose)
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LC50 (median concentration)
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LCLo (lowest published)
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1000–3000 ppm (guinea pig, 3 hr) 12,022 ppm (cat, 7 hr) | ||
NIOSH (US health exposure limits): | |||
PEL (Permissible)
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TWA 100 ppm (360 mg/m3) [skin][1] | ||
REL (Recommended)
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Ca C 1 ppm (3.6 mg/m3) [30-minute][1] | ||
IDLH (Immediate danger)
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Ca [500 ppm][1] | ||
Related compounds | |||
Related compounds
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Oxane Trioxane Tetroxane Pentoxane | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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1,4-Dioxane (/daɪˈɒkseɪn/) is a heterocyclic organic compound, classified as an ether. It is a colorless liquid with a faint sweet odor similar to that of diethyl ether. The compound is often called simply dioxane because the other dioxane isomers (1,2- and 1,3-) are rarely encountered.
Dioxane is used as a solvent for a variety of practical applications as well as in the laboratory, and also as a stabilizer for the transport of chlorinated hydrocarbons in aluminium containers.[3]