| 2021 season | |||
|---|---|---|---|
| President | Shohruh Saidov | ||
| Manager | Vitaliy Levchenko Mubin Ergashev (Interim) (AFC Champions League matches) | ||
| Stadium | Republican Stadium | ||
| Tajik League | Champions | ||
| Tajikistan Cup | Runners-Up | ||
| Super Cup | Winners | ||
| AFC Champions League | Round of 16 | ||
| Top goalscorer | League: Manuchekhr Dzhalilov (18) All: Manuchekhr Dzhalilov (23) | ||
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The FC Istiklol 2021 season was Istiklol's thirteenth Tajik League season, of which they are defending Tajik League Champions, whilst they also participated in the Tajik Cup, Tajik Supercup and AFC Champions League.