| Race details | |
|---|---|
| 1st round of the 2022 IndyCar season | |
 Layout of the Streets of St. Petersburg | |
| Date | February 27, 2022 |
| Official name | Firestone Grand Prix of St. Petersburg |
| Location | Streets of St. Petersburg |
| Course | Temporary street circuit 1.800 mi / 2.897 km |
| Distance | 100 laps 180.000 mi / 289.682 km |
| Pole position | |
| Driver |  Scott McLaughlin (Team Penske) |
| Time | 00:59.4821 |
| Fastest lap | |
| Driver |  Conor Daly (Ed Carpenter Racing) |
| Time | 01:00.9868 (on lap 53 of 100) |
| Podium | |
| First | Scott McLaughlin (Team Penske) |
| Second |  Álex Palou (Chip Ganassi Racing) |
| Third |  Will Power (Team Penske) |
The 2022 Firestone Grand Prix of St. Petersburg was an IndyCar motor race held on February 27, 2022 at the Streets of St. Petersburg in St. Petersburg, Florida. It was the season opener of the 2022 IndyCar Series. The race lasted for 100 laps.
Scott McLaughlin of Team Penske scored his first pole in qualifying and claimed his first race victory in the series over Álex Palou, after leading the most laps in the race. Will Power, McLaughlin's teammate, finished third to complete the podium.