In music, 22 equal temperament, called 22-TET, 22-EDO, or 22-ET, is the tempered scale derived by dividing the octave into 22 equal steps (equal frequency ratios). Each step represents a frequency ratio of 22√2, or 54.55 cents ().
When composing with 22-ET, one needs to take into account a variety of considerations. Considering the 5-limit, there is a difference between 3 fifths and the sum of 1 fourth and 1 major third. It means that, starting from C, there are two A's—one 16 steps and one 17 steps away. There is also a difference between a major tone and a minor tone. In C major, the second note (D) will be 4 steps away. However, in A minor, where A is 6 steps below C, the fourth note (D) will be 9 steps above A, so 3 steps above C. So when switching from C major to A minor, one needs to slightly change the D note. These discrepancies arise because, unlike 12-ET, 22-ET does not temper out the syntonic comma of 81/80, but instead exaggerates its size by mapping it to one step.
In the 7-limit, the septimal minor seventh (7/4) can be distinguished from the sum of a fifth (3/2) and a minor third (6/5), and the septimal subminor third (7/6) is different from the minor third (6/5). This mapping tempers out the septimal comma of 64/63, which allows 22-ET to function as a "Superpythagorean" system where four stacked fifths are equated with the septimal major third (9/7) rather than the usual pental third of 5/4. This system is a "mirror image" of septimal meantone in many ways: meantone systems tune the fifth flat so that intervals of 5 are simple while intervals of 7 are complex, superpythagorean systems have the fifth tuned sharp so that intervals of 7 are simple while intervals of 5 are complex. The enharmonic structure is also reversed: sharps are sharper than flats, similar to Pythagorean tuning (and by extension 53 equal temperament), but to a greater degree.
Finally, 22-ET has a good approximation of the 11th harmonic, and is in fact the smallest equal temperament to be consistent in the 11-limit.
The net effect is that 22-ET allows (and to some extent even forces) the exploration of new musical territory, while still having excellent approximations of common practice consonances.