Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.[5][6]
AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin.[7] AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome.[8] Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), resulting in caspase-1 binding, and forming of AIM2 inflammasome. This signaling contributes to the defense against bacterial and viral DNA.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163568 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037860 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, Trapani JA, et al. (July 1997). "Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma". Oncogene. 15 (4): 453–7. doi:10.1038/sj.onc.1201206. PMID 9242382. S2CID 11152041.
- ^ "Entrez Gene: AIM2 absent in melanoma 2".
- ^ Man SM, Karki R, Kanneganti TD (February 2016). "AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity". European Journal of Immunology. 46 (2): 269–80. doi:10.1002/eji.201545839. PMC 4758349. PMID 26626159.
- ^ Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, Roberts TL, et al. (August 2012). "The mammalian PYHIN gene family: phylogeny, evolution and expression". BMC Evolutionary Biology. 12 (1): 140. Bibcode:2012BMCEE..12..140C. doi:10.1186/1471-2148-12-140. PMC 3458909. PMID 22871040.