Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene.[5][6] Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel[7] and a bicarbonate channel.[8] additionally Anoctamin-1 is apical iodide channel. It is expressed in smooth muscle, epithelial cells,[9] vomeronasal neurons,[10] olfactory sustentacular cells,[11] and is highly expressed in interstitial cells of Cajal (ICC) throughout the gastrointestinal tract.[12]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131620 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031075 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: anoctamin 1, calcium activated chloride channel".
- ^ Katoh M, Katoh M (June 2003). "FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products". International Journal of Oncology. 22 (6): 1375–81. doi:10.3892/ijo.22.6.1375. PMID 12739008.
- ^ Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, et al. (October 2008). "TMEM16A confers receptor-activated calcium-dependent chloride conductance". Nature. 455 (7217): 1210–5. Bibcode:2008Natur.455.1210Y. doi:10.1038/nature07313. PMID 18724360. S2CID 205214858.
- ^ Jung J, Nam JH, Park HW, Oh U, Yoon JH, Lee MG (January 2013). "Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin". Proceedings of the National Academy of Sciences of the United States of America. 110 (1): 360–5. Bibcode:2013PNAS..110..360J. doi:10.1073/pnas.1211594110. PMC 3538232. PMID 23248295.
- ^ Cite error: The named reference
ANO1 epithelial secretionwas invoked but never defined (see the help page). - ^ Amjad A, Hernandez-Clavijo A, Pifferi S, Maurya DK, Boccaccio A, Franzot J, et al. (April 2015). "Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons". The Journal of General Physiology. 145 (4): 285–301. doi:10.1085/jgp.201411348. PMC 4380210. PMID 25779870.
- ^ Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya DK, Rock JR, Harfe BD, Menini A, Pifferi S (1 July 2019). "TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium". The Journal of General Physiology. 151 (7): 954–966. doi:10.1085/jgp.201812310. ISSN 0022-1295. PMC 6605691. PMID 31048412.
- ^ Cite error: The named reference
ICC reviewwas invoked but never defined (see the help page).