Back أباكافير/لاميفودين Arabic Abacavir/lamivudine Welsh Abacavir/lamivudina Spanish Աբակավիր/Լամիվուդին Armenian Abacavir/lamivudina Italian 아바카비르/라미부딘 Korean ଆବାକାଭିର/ଲାମିଭୁଡିନ OR Абакавир/Ламивудин Russian Abakavir/lamivudin Serbo-Croatian Abakavir/lamivudin Slovenian
 | |
| Combination of | |
|---|---|
| Abacavir | Nucleotide analogue reverse transcriptase inhibitor |
| Lamivudine | Nucleotide analogue reverse transcriptase inhibitor |
| Clinical data | |
| Trade names | Kivexa, Epzicom, others |
| AHFS/Drugs.com | Professional Drug Facts |
| MedlinePlus | a696011 |
| Pregnancy category |
|
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| UNII | |
| KEGG | |
| NIAID ChemDB | |
| CompTox Dashboard (EPA) | |
  (what is this?) (verify) | |
Abacavir/lamivudine, sold under the brand name Kivexa among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS.[4] It contains abacavir and lamivudine.[4] It is generally recommended for use with other antiretrovirals.[4] It is commonly used as part of the preferred treatment in children.[5] It is taken by mouth as a tablet.[4]
Common side effects include trouble sleeping, headache, depression, feeling tired, nausea, rash, and fever.[4] Serious side effects may include high blood lactate levels, allergic reactions, and enlargement of the liver.[4] It is not recommended in people with a specific gene known as HLA-B*5701.[4] Safety in pregnancy has not been well studied but it appears to be okay.[6] Lamivudine and abacavir are both nucleoside reverse transcriptase inhibitors (NRTI).[4]
Abacavir/lamivudine was approved for medical use in the United States in 2004.[4] It is on the World Health Organization's List of Essential Medicines.[7]
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ "CAVADEXA, ABADINE, ABALAMID HETERO, BACAMID, LAMAVIR 600/300 (Hetero Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 13 January 2023. Retrieved 15 April 2023.
- ^ "Kivexa EPAR". European Medicines Agency. 17 September 2018. Retrieved 16 November 2020.
- ^ a b c d e f g h i "Abacavir and Lamivudine Tablets". Teva Pharmaceuticals USA. Archived from the original on 6 February 2017. Retrieved 28 November 2016.
- ^ World Health Organization (2015). The selection and use of essential medicines. Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. pp. 45–46. hdl:10665/189763. ISBN 9789241209946. ISSN 0512-3054. WHO technical report series;994.
- ^ "Abacavir / lamivudine (Epzicom) Use During Pregnancy". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 4 December 2016.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.