Adenovirus E1B protein usually refers to one of two proteins transcribed from the E1B gene of the adenovirus: a 55kDa protein and a 19kDa protein. These two proteins are needed to block apoptosis in adenovirus-infected cells. E1B proteins work to prevent apoptosis that is induced by the small adenovirus E1A protein, which stabilizes p53, a tumor suppressor.[1][2]
- ^ Lowe, SW; Ruley, HE (1993). "Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis". Genes & Development. 7 (4): 535–545. doi:10.1101/gad.7.4.535. PMID 8384579.
- ^ White, E; Cipriani, R (January 10, 1990). "Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein". Molecular Cell Biology. 10 (1): 120–130. doi:10.1128/MCB.10.1.120. PMC 360719. PMID 2136765.