Alclometasone

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Alclometasone

Clinical data
Trade names	Aclovate
AHFS/Drugs.com	Monograph
MedlinePlus	a604021
Routes of administration	Topical
ATC code	D07AB10 (WHO) S01BA10 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	3% systemically (topical)
Metabolism	Hepatic
Onset of action	Eczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days [1]
Identifiers
IUPAC name (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-Chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS Number	67452-97-5 Y
PubChem CID	5311000
DrugBank	DB00240 Y
ChemSpider	4470541 Y
UNII	136H45TB7B
ChEBI	CHEBI:53776 Y
ChEMBL	ChEMBL1201361 N
Chemical and physical data
Formula	C22H29ClO5
Molar mass	408.92 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl
InChI InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1 Y Key:FJXOGVLKCZQRDN-PHCHRAKRSA-N Y
NY (what is this?)  (verify)

Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.^[2]

The prodrug alclometasone dipropionate was originally marketed under the brand name Aclovate by GlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available.