Group of peptide hormones in mammals
AGT |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2WXW, 2X0B, 4APH,%%s1N9U, 1N9V,%%s1N9V, 1N9U, 3CK0, 4AA1, 4APH, 5E2Q |
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Identifiers |
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Aliases | AGT, ANHU, SERPINA8, hFLT1, angiotensinogen |
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External IDs | MGI: 87963; HomoloGene: 14; GeneCards: AGT; OMA:AGT - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - liver
- right lobe of liver
- external globus pallidus
- dorsal motor nucleus of vagus nerve
- superior vestibular nucleus
- pars reticulata
- paraflocculus of cerebellum
- inferior olivary nucleus
- ventral tegmental area
- amygdala
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| Top expressed in | - left lobe of liver
- parotid gland
- lumbar subsegment of spinal cord
- paraventricular nucleus of hypothalamus
- central gray substance of midbrain
- deep cerebellar nuclei
- dorsal tegmental nucleus
- superior colliculus
- globus pallidus
- medulla oblongata
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| More reference expression data |
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BioGPS | |
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Wikidata |
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Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.
An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. Angiotensin was isolated in the late 1930s (first named 'angiotonin' or 'hypertensin') and subsequently characterized and synthesized by groups at the Cleveland Clinic and Ciba laboratories.[5]