B4GALT5

B4GALT5
Identifiers
Aliases	B4GALT5, B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V, beta-1,4-galactosyltransferase 5
External IDs	OMIM: 604016; MGI: 1927169; HomoloGene: 3507; GeneCards: B4GALT5; OMA:B4GALT5 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,713,878 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	167,191,103 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; palpebral conjunctiva; ; trachea; ; trabecular bone; ; pericardium; ; mucosa of urinary bladder; ; tibialis anterior muscle; ; secondary oocyte; ; pancreatic ductal cell; ; olfactory zone of nasal mucosa;
	Top expressed in
	gastrula; ; yolk sac; ; zygote; ; decidua; ; right kidney; ; proximal tubule; ; tail of embryo; ; genital tubercle; ; secondary oocyte; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; galactosyltransferase activity; metal ion binding; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; N-acetyllactosamine synthase activity; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	protein glycosylation; keratan sulfate biosynthetic process; O-glycan processing; carbohydrate metabolic process; poly-N-acetyllactosamine biosynthetic process; ganglioside biosynthetic process via lactosylceramide; central nervous system neuron axonogenesis; central nervous system myelination; regulation of protein stability; positive regulation of embryonic development; neuron maturation; lipid metabolism; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9334
	56336
	ENSG00000158470
	ENSMUSG00000017929
	O43286
	Q9JMK0
	NM_004776
	NM_019835
	NP_004767
	NP_062809
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-1,4-galactosyltransferase 5 is an enzyme that in humans is encoded by the B4GALT5 gene.^[5]^[6]^[7]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158470 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017929 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology. 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID 9597550.
^ Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I (Feb 1998). "Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase". Proc Natl Acad Sci U S A. 95 (2): 472–7. Bibcode:1998PNAS...95..472S. doi:10.1073/pnas.95.2.472. PMC 18444. PMID 9435216.
^ ^a ^b "Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158470 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017929 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9597550-5] Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology. 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID 9597550.

[pmid9435216-6] Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I (Feb 1998). "Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase". Proc Natl Acad Sci U S A. 95 (2): 472–7. Bibcode:1998PNAS...95..472S. doi:10.1073/pnas.95.2.472. PMC 18444. PMID 9435216.

[entrez-7] "Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5".

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B4GALT5

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