Bcl-2

BCL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
Identifiers
Aliases	BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
External IDs	OMIM: 151430; MGI: 88138; HomoloGene: 527; GeneCards: BCL2; OMA:BCL2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.33 Start 63,123,346 bp[1] End 63,320,128 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E2.1|1 49.76 cM Start 106,465,908 bp[2] End 106,642,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve superficial temporal artery Achilles tendon epithelium of colon inferior olivary nucleus optic nerve trigeminal ganglion internal globus pallidus external globus pallidus caput epididymis Top expressed in ascending aorta aortic valve Rostral migratory stream vestibular membrane of cochlear duct iris lumbar spinal ganglion mesenteric lymph nodes ciliary body blood vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase binding transcription factor binding protein phosphatase 2A binding channel inhibitor activity protein homodimerization activity channel activity protease binding protein binding sequence-specific DNA binding BH3 domain binding identical protein binding protein heterodimerization activity ubiquitin protein ligase binding Cellular component cytoplasm cytosol nuclear membrane membrane mitochondrion nucleus mitochondrial membranes myelin sheath mitochondrial outer membrane endoplasmic reticulum pore complex integral component of membrane intracellular anatomical structure endoplasmic reticulum membrane nucleoplasm protein-containing complex Biological process negative regulation of neuron apoptotic process intrinsic apoptotic signaling pathway in response to oxidative stress ureteric bud development renal system process organ growth T cell differentiation in thymus lymphocyte homeostasis response to steroid hormone positive regulation of catalytic activity ear development glomerulus development post-embryonic development cellular response to DNA damage stimulus T cell homeostasis negative regulation of ossification negative regulation of G1/S transition of mitotic cell cycle positive regulation of smooth muscle cell migration regulation of protein localization T cell differentiation B cell lineage commitment response to ischemia regulation of mitochondrial membrane permeability humoral immune response defense response to virus mesenchymal cell development positive regulation of multicellular organism growth animal organ morphogenesis developmental pigmentation hair follicle morphogenesis B cell differentiation cell population proliferation metanephros development melanocyte differentiation negative regulation of autophagy positive regulation of neuron maturation negative regulation of myeloid cell apoptotic process cellular response to hypoxia pigment granule organization negative regulation of cell population proliferation B cell receptor signaling pathway cellular response to organic substance regulation of apoptotic process response to cytokine cellular response to glucose starvation regulation of protein stability ossification positive regulation of melanocyte differentiation axon regeneration kidney development actin filament organization thymus development negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway response to nicotine spleen development endoplasmic reticulum calcium ion homeostasis positive regulation of skeletal muscle fiber development response to oxidative stress lymphoid progenitor cell differentiation positive regulation of peptidyl-serine phosphorylation CD8-positive, alpha-beta T cell lineage commitment reactive oxygen species metabolic process negative regulation of retinal cell programmed cell death branching involved in ureteric bud morphogenesis gland morphogenesis positive regulation of cell growth positive regulation of B cell proliferation negative regulation of cell growth response to gamma radiation positive regulation of intrinsic apoptotic signaling pathway response to toxic substance digestive tract morphogenesis neuron apoptotic process male gonad development regulation of protein heterodimerization activity regulation of glycoprotein biosynthetic process regulation of viral genome replication female pregnancy negative regulation of mitochondrial depolarization protein dephosphorylation protein polyubiquitination cellular calcium ion homeostasis B cell homeostasis behavioral fear response oocyte development regulation of cell-matrix adhesion response to iron ion negative regulation of cell migration regulation of autophagy positive regulation of developmental pigmentation developmental growth regulation of transmembrane transporter activity ovarian follicle development regulation of gene expression negative regulation of calcium ion transport into cytosol negative regulation of osteoblast proliferation homeostasis of number of cells within a tissue pigmentation response to radiation regulation of catalytic activity peptidyl-threonine phosphorylation regulation of protein homodimerization activity negative regulation of anoikis response to hydrogen peroxide T cell lineage commitment cochlear nucleus development leukocyte homeostasis regulation of programmed cell death regulation of calcium ion transport axonogenesis negative regulation of cellular pH reduction response to glucocorticoid regulation of cell cycle regulation of mitochondrial membrane potential melanin metabolic process focal adhesion assembly positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway B cell proliferation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress immune system development apoptotic mitochondrial changes peptidyl-serine phosphorylation regulation of nitrogen utilization cell morphogenesis positive regulation of cell population proliferation negative regulation of reactive oxygen species metabolic process response to UV-B regulation of developmental pigmentation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway via death domain receptors release of cytochrome c from mitochondria negative regulation of mitotic cell cycle extrinsic apoptotic signaling pathway in absence of ligand apoptotic process transmembrane transport intrinsic apoptotic signaling pathway in response to DNA damage growth cell-cell adhesion cytokine-mediated signaling pathway negative regulation of apoptotic process hemopoiesis regulation of growth negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 596 12043 Ensembl ENSG00000171791 ENSMUSG00000057329 UniProt P10415 P10417 RefSeq (mRNA) NM_000633 NM_000657 NM_009741 NM_177410 RefSeq (protein) NP_000624 NP_000648 NP_033871 NP_803129 Location (UCSC) Chr 18: 63.12 – 63.32 Mb Chr 1: 106.47 – 106.64 Mb PubMed search [3] [4]
Wikidata
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Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) ^[5] while other BCL2 family members can either inhibit or induce it.^[6][7] It was the first apoptosis regulator identified in any organism.^[8]

Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Orthologs^[9] (such as Bcl2 in mice) have been identified in numerous mammals for which complete genome data are available.

Like BCL3, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.