Back بنزنيدازول Arabic Benznidazol German Benzinidazol Spanish بنزنیدازول Persian Bentsnidatsoli Finnish Benznidazole French Benznidazol Croatian Benznidazol Hungarian ベンズニダゾール Japanese ବେଞ୍ଜନିଡାଜୋଲ OR
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| Clinical data | |
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| Trade names | Rochagan, Radanil[1] |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | High |
| Metabolism | Liver |
| Elimination half-life | 12 hours |
| Excretion | Kidney and fecal |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.153.448 |
| Chemical and physical data | |
| Formula | C12H12N4O3 |
| Molar mass | 260.253 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 188.5 to 190 °C (371.3 to 374.0 °F) |
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Benznidazole is an antiparasitic medication used in the treatment of Chagas disease.[2] While it is highly effective in early disease, the effectiveness decreases in those who have long-term infection.[3] It is the first-line treatment given its moderate side effects compared to nifurtimox.[1] It is taken by mouth.[2]
Side effects are fairly common.[4] They include rash, numbness, fever, muscle pain, loss of appetite, and trouble sleeping.[4][5] Rare side effects include bone marrow suppression which can lead to low blood cell levels.[1][5] It is not recommended during pregnancy or in people with severe liver or kidney disease.[4][3] Benznidazole is in the nitroimidazole family of medication and works by the production of free radicals.[5][6]
Benznidazole came into medical use in 1971.[2] It is on the World Health Organization's List of Essential Medicines.[7] As of 2012, Laboratório Farmacêutico do Estado de Pernambuco, a government run pharmaceutical company in Brazil was the only producer.[8][needs update]
- ^ a b c Bern C, Montgomery SP, Herwaldt BL, Rassi A, Marin-Neto JA, Dantas RO, et al. (November 2007). "Evaluation and treatment of chagas disease in the United States: a systematic review". JAMA. 298 (18): 2171–2181. doi:10.1001/jama.298.18.2171. PMID 18000201. Archived from the original on 2016-11-07.
- ^ a b c d "Benznidazole tablet". DailyMed. 12 November 2019. Retrieved 13 October 2020.
- ^ a b "Chagas disease". World Health Organization. March 2016. Archived from the original on 27 February 2014. Retrieved 7 December 2016.
- ^ a b c "Antiparasitic Treatment". Centers for Disease Control and Prevention (CDC). Archived from the original on 2016-11-06. Retrieved 2016-11-05.
- ^ a b c Castro JA, de Mecca MM, Bartel LC (August 2006). "Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)". Human & Experimental Toxicology. 25 (8): 471–479. Bibcode:2006HETox..25..471C. doi:10.1191/0960327106het653oa. hdl:11336/82805. PMID 16937919. S2CID 8980212.
- ^ Urbina JA. "Nuevas drogas para el tratamiento etiológico de la Enfermedad de Chagas" (in Spanish). Archived from the original on May 8, 2012. Retrieved March 24, 2012.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Treatment for Chagas: Enter Supplier Number Two | End the Neglect". endtheneglect.org. 21 March 2012. Archived from the original on 6 November 2016. Retrieved 7 December 2016.