Bone healing

Bone healing of a fracture by forming a callus as shown by X-ray.

Bone healing, or fracture healing, is a proliferative physiological process in which the body facilitates the repair of a bone fracture.

Generally, bone fracture treatment consists of a doctor reducing (pushing) displaced bones back into place via relocation with or without anaesthetic, stabilizing their position to aid union, and then waiting for the bone's natural healing process to occur.

Adequate nutrient intake has been found to significantly affect the integrity of the fracture repair.[1] Age, bone type, drug therapy and pre-existing bone pathology are factors that affect healing. The role of bone healing is to produce new bone without a scar as seen in other tissues which would be a structural weakness or deformity.[2]

The process of the entire regeneration of the bone can depend on the angle of dislocation or fracture. While the bone formation usually spans the entire duration of the healing process, in some instances, bone marrow within the fracture has healed two or fewer weeks before the final remodelling phase.[citation needed]

While immobilization and surgery may facilitate healing, a fracture ultimately heals through physiological processes. The healing process is mainly determined by the periosteum (the connective tissue membrane covering the bone). The periosteum is one source of precursor cells that develop into chondroblasts and osteoblasts that are essential to the healing of bone. Other sources of precursor cells are the bone marrow (when present), endosteum, small blood vessels, and fibroblasts.[3]

  1. ^ Karpouzos, A.; Diamantis, E.; Farmaki, P.; Savvanis, S.; Troupis, T. (2017). "Nutritional Aspects of Bone Health and Fracture Healing". Journal of Osteoporosis. 2017: 1–10. doi:10.1155/2017/4218472. PMC 5804294. PMID 29464131.
  2. ^ Gómez-Barrena E, Rosset P, Lozano D, Stanovici J, Ermthaller C, Gerbhard F (January 2015). "Bone fracture healing: cell therapy in delayed unions and nonunions". Bone. 70: 93–101. doi:10.1016/j.bone.2014.07.033. PMID 25093266.
  3. ^ Ferretti C, Mattioli-Belmonte M (July 2014). "Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge". World J Stem Cells. 6 (3): 266–277. doi:10.4252/wjsc.v6.i3.266. PMC 4131269. PMID 25126377.

From Wikipedia, the free encyclopedia · View on Wikipedia

Developed by razib.in