C-reactive protein

CRP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B09, 1GNH, 1LJ7, 3L2Y, 3PVN, 3PVO
Identifiers
Aliases	CRP, PTX1, C-reactive protein, pentraxin-related, C-Reactive Protein
External IDs	OMIM: 123260; MGI: 88512; HomoloGene: 128039; GeneCards: CRP; OMA:CRP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 159,712,289 bp[1] End 159,714,589 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 80.13 cM Start 172,525,622 bp[2] End 172,660,598 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver islet of Langerhans gallbladder gonad testicle body of pancreas pancreatic epithelial cell right coronary artery ectocervix epithelium of colon Top expressed in left lobe of liver efferent ductule sexually immature organism human fetus vas deferens lumbar subsegment of spinal cord thymus lumbar spinal ganglion epididymis digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function low-density lipoprotein particle receptor binding calcium ion binding virion binding complement component C1q complex binding protein binding metal ion binding low-density lipoprotein particle binding choline binding identical protein binding Cellular component extracellular region extracellular space Biological process negative regulation of lipid storage positive regulation of superoxide anion generation positive regulation of gene expression inflammatory response acute-phase response negative regulation of macrophage derived foam cell differentiation opsonization defense response to Gram-positive bacterium complement activation, classical pathway innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1401 12944 Ensembl ENSG00000132693 ENSMUSG00000037942 UniProt P02741 P14847 RefSeq (mRNA) NM_000567 NM_001329057 NM_001329058 NM_001382703 NM_007768 RefSeq (protein) NP_000558 NP_001315986 NP_001315987 NP_001369632 NP_031794 Location (UCSC) Chr 1: 159.71 – 159.71 Mb Chr 1: 172.53 – 172.66 Mb PubMed search [3] [4]
Wikidata
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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q.^[5]

CRP is synthesized by the liver^[6] in response to factors released by macrophages, T cells and fat cells (adipocytes).^[7] It is a member of the pentraxin family of proteins.^[6] It is not related to C-peptide (insulin) or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.^[8]