CCL18

CCL18
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4MHE
Identifiers
Aliases	CCL18, chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated), AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18, C-C motif chemokine ligand 18
External IDs	OMIM: 603757; HomoloGene: 48154; GeneCards: CCL18; OMA:CCL18 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 36,064,272 bp[1] End 36,072,032 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node upper lobe of left lung appendix rectum right lung duodenum spleen gallbladder right coronary artery left coronary artery n/a More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity protein binding CCR chemokine receptor binding chemokine activity Cellular component extracellular region extracellular space Biological process G protein-coupled receptor signaling pathway monocyte chemotaxis chemokine-mediated signaling pathway cellular response to tumor necrosis factor cell-cell signaling neutrophil chemotaxis chemotaxis cell communication positive regulation of GTPase activity cellular response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma lymphocyte chemotaxis inflammatory response signal transduction antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity positive regulation of inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6362 n/a Ensembl ENSG00000275385 ENSG00000278167 ENSG00000278006 n/a UniProt P55774 n/a RefSeq (mRNA) NM_002988 n/a RefSeq (protein) NP_002979 n/a Location (UCSC) Chr 17: 36.06 – 36.07 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family. The functions of CCL18 have been well studied in laboratory settings, however the physiological effects of the molecule in living organisms have been difficult to characterize because there is no similar protein in rodents that can be studied. The receptor for CCL18 has been identified in humans only recently, which will help scientists understand the molecule's role in the body.

CCL18 is produced and secreted mainly by innate immune system, and has effects mainly on the adaptive immune system. It was previously known as Pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1), alternative macrophage activation-associated CC chemokine-1 (AMAC-1), and macrophage inflammatory protein-4 (MIP-4).