| TMEM16 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Cartoon representation of a mTMEM16A chloride channel based on a cryoelectron microscopy reconstruction.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Apoctamin | ||||||||
| Pfam | PF04547 | ||||||||
| InterPro | IPR032394 | ||||||||
| TCDB | 1.A.17 | ||||||||
| OPM superfamily | 369 | ||||||||
| Membranome | 219 | ||||||||
| |||||||||
The Calcium-Dependent Chloride Channel (Ca-ClC) proteins (or calcium-activated chloride channels (CaCCs),[2] are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory (CLCA),[3] bestrophin (BEST),[4][5] and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels[4][5][6][7] ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis.[6] In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors.[8] These eukaryotic proteins are "required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability" in animals.[9][10] Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues (aas) in length and exhibit 7 to 10 transmembrane segments (TMSs).
- ^ PDB: 5oyb; Paulino C, Kalienkova V, Lam A, Neldner Y, Dutzler R (December 2017). "Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM" (PDF). Nature. 552 (7685): 421–425. Bibcode:2017Natur.552..421P. doi:10.1038/nature24652. PMID 29236691. S2CID 4457894.
- ^ Cite error: The named reference
pmid15709976was invoked but never defined (see the help page). - ^ Cite error: The named reference
ncbiGene1179was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
pmid21194364was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
pmid19783045was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
ICC reviewwas invoked but never defined (see the help page). - ^ Cite error: The named reference
brunner2014was invoked but never defined (see the help page). - ^ Cite error: The named reference
PUB00020852was invoked but never defined (see the help page). - ^ Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (October 2008). "TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity". Science. 322 (5901): 590–4. Bibcode:2008Sci...322..590C. doi:10.1126/science.1163518. PMID 18772398. S2CID 52870095.
- ^ Pang C, Yuan H, Ren S, Chen Y, An H, Zhan Y (1 January 2014). "TMEM16A/B associated CaCC: structural and functional insights". Protein and Peptide Letters. 21 (1): 94–9. doi:10.2174/09298665113206660098. PMID 24151904.