Carbon monoxide-releasing molecules

Structure of RuCl(gly)(CO)₃, known as CORM-3.

Carbon monoxide-releasing molecules (CORMs) are chemical compounds designed to release controlled amounts of carbon monoxide (CO). CORMs are being developed as potential therapeutic agents to locally deliver CO to cells and tissues, thus overcoming limitations of CO gas inhalation protocols.

CO is best known for its toxicity in carbon monoxide poisoning at high doses. However, CO is a gasotransmitter and supplemental low dosage of CO has been linked to therapeutic benefits. Pre-clinical research has focused on CO's anti-inflammatory activity with significant applications in cardiovascular disease, oncology, transplant surgery, and neuroprotection.^[1]

^ Motterlini R, Otterbein LE (September 2010). "The therapeutic potential of carbon monoxide". review article. Nature Reviews. Drug Discovery. 9 (9): 728–743. doi:10.1038/nrd3228. PMID 20811383. S2CID 205477130.

[1] Motterlini R, Otterbein LE (September 2010). "The therapeutic potential of carbon monoxide". review article. Nature Reviews. Drug Discovery. 9 (9): 728–743. doi:10.1038/nrd3228. PMID 20811383. S2CID 205477130.

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Carbon monoxide-releasing molecules

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