Catenin beta-1

CTNNB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G3J, 1JDH, 1JPW, 1LUJ, 1P22, 1QZ7, 1T08, 1TH1, 2GL7, 2Z6H, 3DIW, 3SL9, 3SLA, 3TX7, 4DJS, 3FQN, 3FQR
Identifiers
Aliases	CTNNB1, CTNNB, MRD19, armadillo, catenin beta 1, EVR7, NEDSDV
External IDs	OMIM: 116806; MGI: 88276; HomoloGene: 1434; GeneCards: CTNNB1; OMA:CTNNB1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 41,194,741 bp[1] End 41,260,096 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 72.19 cM Start 120,758,282 bp[2] End 120,789,573 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone periodontal fiber Achilles tendon stromal cell of endometrium seminal vesicula canal of the cervix ganglionic eminence right ovary mucosa of sigmoid colon epithelium of colon Top expressed in primitive streak vestibular sensory epithelium molar maxillary prominence hair follicle left lung lobe ciliary body vas deferens mandibular prominence urothelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding SMAD binding chromatin binding signal transducer activity double-stranded DNA binding protein C-terminus binding protein kinase binding kinase binding androgen receptor binding transmembrane transporter binding estrogen receptor binding I-SMAD binding protein phosphatase binding transcription factor binding transcription coactivator activity alpha-catenin binding enzyme binding RNA polymerase II core promoter sequence-specific DNA binding protein heterodimerization activity cadherin binding disordered domain specific binding Cellular component adherens junction beta-catenin destruction complex protein-DNA complex lamellipodium beta-catenin-TCF complex beta-catenin-TCF7L2 complex centrosome Z discdkac bicellular tight junction transcription regulator complex lateral plasma membrane cytoplasm cell cortex apical part of cell spindle pole Scrib-APC-beta-catenin complex catenin-TCF7L2 complex flotillin complex intercalated disc nucleus cell-cell junction membrane Wnt signalosome basolateral plasma membrane plasma membrane cytoskeleton extracellular exosome nucleoplasm microtubule organizing center cell periphery apical junction complex cell projection membrane focal adhesion microvillus membrane fascia adherens cytosol cell junction perinuclear region of cytoplasm catenin complex synapse intracellular anatomical structure protein-containing complex presynaptic membrane cell projection postsynaptic membrane Schaffer collateral - CA1 synapse presynaptic active zone cytoplasmic component postsynaptic density, intracellular component Biological process embryonic brain development negative regulation of cell population proliferation renal vesicle formation positive regulation of MAPK cascade proximal/distal pattern formation positive regulation of neuroblast proliferation chemical synaptic transmission central nervous system vasculogenesis renal inner medulla development transcription, DNA-templated positive regulation of neuron apoptotic process canonical Wnt signaling pathway embryonic foregut morphogenesis endoderm formation endodermal cell fate commitment synapse organization trachea formation cellular process positive regulation of telomere maintenance via telomerase neural plate development negative regulation of protein sumoylation lung cell differentiation vasculogenesis lung induction hemopoiesis kidney development positive regulation of gene expression adherens junction organization renal outer medulla development thymus development regulation of myelination positive regulation of cell population proliferation epithelial tube branching involved in lung morphogenesis bone resorption epithelial cell differentiation involved in prostate gland development regulation of euchromatin binding hair follicle morphogenesis hair follicle placode formation neuron migration negative regulation of chondrocyte differentiation fungiform papilla formation positive regulation of type I interferon production negative regulation of mitotic cell cycle, embryonic ectoderm development trachea morphogenesis T cell differentiation in thymus pancreas development cranial ganglion development regulation of apoptotic process lung development positive regulation of skeletal muscle tissue development synaptic vesicle transport positive regulation of telomerase activity morphogenesis of embryonic epithelium renal system development oocyte development hair cycle process embryonic axis specification embryonic forelimb morphogenesis anterior/posterior axis specification positive regulation of endothelial cell differentiation regulation of transcription by RNA polymerase II animal organ development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis dorsal/ventral axis specification positive regulation of muscle cell differentiation positive regulation of apoptotic process regulation of protein localization to cell surface androgen receptor signaling pathway nervous system development forebrain development hair cell differentiation negative regulation of transcription by RNA polymerase II regulation of epithelial cell differentiation positive regulation of histone H3-K4 methylation embryonic digit morphogenesis endothelial tube morphogenesis osteoclast differentiation regulation of transcription, DNA-templated regulation of osteoclast differentiation neuron differentiation epithelial to mesenchymal transition cell fate specification odontogenesis of dentin-containing tooth midbrain development positive regulation of mesenchymal cell proliferation positive regulation of heparan sulfate proteoglycan biosynthetic process smooth muscle cell differentiation glial cell fate determination cell fate determination positive regulation of determination of dorsal identity regulation of T cell proliferation gastrulation with mouth forming second negative regulation of apoptotic signaling pathway oviduct development cellular response to growth factor stimulus male genitalia development negative regulation of gene expression nephron tubule formation regulation of osteoblast differentiation regulation of angiogenesis cell morphogenesis involved in differentiation cell-matrix adhesion dorsal root ganglion development regulation of cell population proliferation embryonic skeletal limb joint morphogenesis heart development T cell differentiation dorsal/ventral pattern formation layer formation in cerebral cortex canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition positive regulation of osteoblast differentiation negative regulation of osteoclast differentiation regulation of core promoter binding genitalia morphogenesis negative regulation of neuron death cell maturation cell population proliferation branching involved in ureteric bud morphogenesis cell differentiation protein localization to cell surface embryonic hindlimb morphogenesis negative regulation of oligodendrocyte differentiation metanephros morphogenesis regulation of centriole-centriole cohesion limb development positive regulation of epithelial cell proliferation involved in prostate gland development regulation of secondary heart field cardioblast proliferation regulation of fibroblast proliferation regulation of smooth muscle cell proliferation skin development skeletal system development hindbrain development regulation of calcium ion import mesenchymal cell proliferation involved in lung development regulation of nephron tubule epithelial cell differentiation cellular response to indole-3-methanol canonical Wnt signaling pathway involved in negative regulation of apoptotic process regulation of gene expression regulation of cell differentiation stem cell population maintenance regulation of neurogenesis in utero embryonic development lung-associated mesenchyme development negative regulation of cell differentiation positive regulation of I-kappaB kinase/NF-kappaB signaling vasculature development sympathetic ganglion development positive regulation of epithelial cell differentiation positive regulation of branching involved in lung morphogenesis lens morphogenesis in camera-type eye positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast growth factor receptor signaling pathway embryonic heart tube development regulation of centromeric sister chromatid cohesion positive regulation of DNA-templated transcription, initiation positive regulation of transcription, DNA-templated branching involved in blood vessel morphogenesis positive regulation of DNA-binding transcription factor activity cell adhesion negative regulation of transcription, DNA-templated adherens junction assembly positive regulation of transcription by RNA polymerase II Wnt signaling pathway, calcium modulating pathway beta-catenin-TCF complex assembly beta-catenin destruction complex disassembly cranial skeletal system development proteasome-mediated ubiquitin-dependent protein catabolic process Wnt signaling pathway canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation response to estradiol midbrain dopaminergic neuron differentiation entry of bacterium into host cell negative regulation of oxidative stress-induced neuron death positive regulation of core promoter binding viral process negative regulation of angiogenesis negative regulation of epithelial cell differentiation negative regulation of apoptotic process positive regulation of molecular function positive regulation of epithelial cell proliferation negative regulation of neurogenesis regulation of timing of anagen regulation of canonical Wnt signaling pathway synaptic vesicle clustering cell-cell adhesion neuron projection extension positive regulation of neural precursor cell proliferation protein polyubiquitination tissue homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1499 12387 Ensembl ENSG00000168036 ENSMUSG00000006932 UniProt P35222 Q02248 RefSeq (mRNA) NM_001098209 NM_001098210 NM_001904 NM_001330729 NM_001165902 NM_007614 RefSeq (protein) NP_001091679 NP_001091680 NP_001317658 NP_001895 NP_001159374 NP_031640 Location (UCSC) Chr 3: 41.19 – 41.26 Mb Chr 9: 120.76 – 120.79 Mb PubMed search [3] [4]
Wikidata
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Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene.

β-Catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene.^[5][6] In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway.^[7][8][9] It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. β-Catenin is widely expressed in many tissues. In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes.

Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.^[10] Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).