The channelome, sometimes called the "ion channelome", is the complete set of ion channels[1] and porins[2] expressed in a biological tissue or organism.[3] It is analogous to the genome, the metabolome (describing metabolites), the proteome (describing general protein expression), and the microbiome. Characterization of the ion channelome, referred to as channelomics, is a branch of physiology, biophysics, neuroscience, and pharmacology, with particular attention paid to gene expression.[4][5][6] It can be performed by a variety of techniques, including patch clamp electrophysiology, PCR, and immunohistochemistry.[4][7] Channelomics is being used to screen and discover new medicines.[4][8]
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- ^ Barrett-Jolley, R., R. Lewis, et al. (2010). The emerging chondrocyte channelome: Frontiers in Membrane Physiology and Biophysics. doi:10.3389/fphys.2010.00135
- ^ a b c Lehmann-Horn, F.; Jurkat-Rott, K. (2003). "Nanotechnology for neuronal ion channels". Journal of Neurology, Neurosurgery, and Psychiatry. 74 (11): 1466–1475. doi:10.1136/jnnp.74.11.1466. PMC 1738249. PMID 14617700.
- ^ Jurkat-Rott, K.; Lehmann-Horn, F. (2004). "The Patch Clamp Technique in Ion Channel Research". Current Pharmaceutical Biotechnology. 5 (4): 387–395. doi:10.2174/1389201043376715. PMID 15320769.
- ^ Gabashvili, S.; Sokolowski, H.; Morton, C.; Giersch, B. (Sep 2007). "Ion channel gene expression in the inner ear". Journal of the Association for Research in Otolaryngology. 8 (3): 305–328. doi:10.1007/s10162-007-0082-y. ISSN 1525-3961. PMC 2538437. PMID 17541769.
- ^ Perraud, A. L.; Schmitz, C.; Scharenberg, A. M. (2006). Reviews and Protocols in DT40 Research. Subcellular Biochemistry. Vol. 40. pp. 257–270. doi:10.1007/978-1-4020-4896-8_15. ISBN 978-1-4020-4895-1. S2CID 436332.
- ^ Camerino, D. C.; Tricarico, D.; Desaphy, J. F. (Apr 2007). "Ion channel pharmacology". Neurotherapeutics. 4 (2): 184–198. doi:10.1016/j.nurt.2007.01.013. PMID 17395128.