Back تكاثف كلايزن Arabic Condensació de Claisen Catalan Claisenova kondenzace Czech Claisen-kondensation Danish Claisen-Kondensation German Condensación de Claisen Spanish Claiseni kondensatsioon Estonian تراکم کلایزن Persian Claisen-kondensaatio Finnish Condensation de Claisen French
| Claisen condensation | |||||||||||||
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| Named after | Rainer Ludwig Claisen | ||||||||||||
| Reaction type | Condensation reaction | ||||||||||||
| Reaction | |||||||||||||
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| Conditions | |||||||||||||
| Typical solvents | R'-OH
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| Organic Chemistry Portal | claisen-condensation | ||||||||||||
| RSC ontology ID | RXNO:0000043 | ||||||||||||
The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base. The reaction produces a β-keto ester or a β-diketone.[1] It is named after Rainer Ludwig Claisen, who first published his work on the reaction in 1887.[2][3][4] The reaction has often been displaced by diketene-based chemistry, which affords acetoacetic esters.[5]
- ^ Carey, F. A. (2006). Organic Chemistry (6th ed.). New York, NY: McGraw-Hill. ISBN 0-07-111562-5.
- ^ Claisen, L.; Claparede, A. (1881). "Condensationen von Ketonen mit Aldehyden". Berichte der Deutschen Chemischen Gesellschaft. 14 (2): 2460–2468. doi:10.1002/cber.188101402192.
- ^ Claisen, L. (1887). "Ueber die Einführung von Säureradicalen in Ketone". Berichte der Deutschen Chemischen Gesellschaft. 20 (1): 655–657. doi:10.1002/cber.188702001150.
- ^ Hauser, C. R.; Hudson, B. E. Jr. (1942). "The Acetoacetic Ester Condensation and Certain Related Reactions". Organic Reactions. 1: 266–302. doi:10.1002/0471264180.or001.09. ISBN 0471264180.
- ^ Riemenschneider, Wilhelm; Bolt, Hermann M. (2005). "Esters, Organic". Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.a09_565.pub2. ISBN 3527306730.