Cripavirus | |
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Virus classification ![]() | |
(unranked): | Virus |
Realm: | Riboviria |
Kingdom: | Orthornavirae |
Phylum: | Pisuviricota |
Class: | Pisoniviricetes |
Order: | Picornavirales |
Family: | Dicistroviridae |
Genus: | Cripavirus |
Cripavirus is a genus of viruses in the order Picornavirales, in the family Dicistroviridae. Invertebrates serve as natural hosts. There are four species in this genus. Diseases associated with this genus include: DCV: increased reproductive potential; extremely pathogenic when injected with high associated mortality; CrPV: paralysis and death.[1][2] These viruses can produce proteins directly from their RNA genome upon entering a cell; and therefore, does not require an RNA polymerase packaged in with it, as this may be produced from the genome after entering the cell.[3] The name of the cripavirus family originates from its most famous member the Cricket Paralysis Virus.[3] Which was made famous by its rather unusual IRES (Internal Ribosome Entry Site): the Cripavirus IRES. The Cripavirus IRES is an RNA element that allows the virus to bind the ribosome and translate without a need for any initiation factors[4] – as initiation is the most regulated step of translation this allows the virus to avoid many mechanisms to inhibit viral activity.