| Cripavirus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Picornavirales |
| Family: | Dicistroviridae |
| Genus: | Cripavirus |
Cripavirus is a genus of viruses in the order Picornavirales, in the family Dicistroviridae. Invertebrates serve as natural hosts. There are four species in this genus. Diseases associated with this genus include: DCV: increased reproductive potential; extremely pathogenic when injected with high associated mortality; CrPV: paralysis and death.[1][2] These viruses can produce proteins directly from their RNA genome upon entering a cell; and therefore, does not require an RNA polymerase packaged in with it, as this may be produced from the genome after entering the cell.[3] The name of the cripavirus family originates from its most famous member the Cricket Paralysis Virus.[3] Which was made famous by its rather unusual IRES (Internal Ribosome Entry Site): the Cripavirus IRES. The Cripavirus IRES is an RNA element that allows the virus to bind the ribosome and translate without a need for any initiation factors[4] – as initiation is the most regulated step of translation this allows the virus to avoid many mechanisms to inhibit viral activity.
- ^ "Viral Zone". ExPASy. Retrieved 15 June 2015.
- ^ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 20 May 2021.
- ^ a b International Committee on the Taxonomy of Viruses Archived 1 December 2008 at the Wayback Machine
- ^ Balvay, L.; Soto Rifo, R.; Ricci, E. P.; Decimo, D.; Ohlmann, T. (2009), "Structure and Function of Regulatory RNA Elements", Biochimica et Biophysica Acta, 1789 (9–10): 542–557, doi:10.1016/j.bbagrm.2009.07.005, PMID 19632368