Dicer

DICER1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ
Identifiers
Aliases	DICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW
External IDs	OMIM: 606241; MGI: 2177178; HomoloGene: 13251; GeneCards: DICER1; OMA:DICER1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.13 Start 95,086,228 bp[1] End 95,158,010 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 E|12 54.83 cM Start 104,654,001 bp[2] End 104,718,211 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis caput epididymis optic nerve trabecular bone corpus epididymis mucosa of paranasal sinus visceral pleura oral cavity parietal pleura inferior ganglion of vagus nerve Top expressed in zygote secondary oocyte primary oocyte tail of embryo genital tubercle mandibular prominence medullary collecting duct renal corpuscle abdominal wall primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding helicase activity protein domain specific binding pre-miRNA binding metal ion binding endoribonuclease activity endoribonuclease activity, producing 5'-phosphomonoesters protein binding siRNA binding RNA binding nuclease activity double-stranded RNA binding endonuclease activity hydrolase activity ATP binding ribonuclease III activity DNA binding deoxyribonuclease I activity Cellular component cytoplasm cytosol RISC complex growth cone ARC complex RISC-loading complex axon dendrite nucleus endoplasmic reticulum-Golgi intermediate compartment extracellular exosome Biological process neuron projection morphogenesis RNA processing negative regulation of transcription by RNA polymerase II peripheral nervous system myelin formation pre-miRNA processing positive regulation of myelination nerve development RNA phosphodiester bond hydrolysis, endonucleolytic positive regulation of Schwann cell differentiation negative regulation of Schwann cell proliferation production of miRNAs involved in gene silencing by miRNA miRNA metabolic process production of siRNA involved in RNA interference gene silencing apoptotic DNA fragmentation negative regulation of tumor necrosis factor production NIK/NF-kappaB signaling negative regulation of gene expression tube formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23405 192119 Ensembl ENSG00000100697 ENSMUSG00000041415 UniProt Q9UPY3 Q8R418 RefSeq (mRNA) NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438 NM_148948 RefSeq (protein) NP_001182502 NP_001258211 NP_001278557 NP_085124 NP_803187 NP_683750 Location (UCSC) Chr 14: 95.09 – 95.16 Mb Chr 12: 104.65 – 104.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20–25 base pairs long with a two-base overhang on the 3′-end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component Argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).