Draft:OrthoRep

Submission declined on 24 July 2024 by Mgp28 (talk). This draft's references do not show that the subject qualifies for a Wikipedia article. In summary, the draft needs multiple published sources that are: in-depth (not just passing mentions about the subject) reliable secondary independent of the subject Make sure you add references that meet these criteria before resubmitting. Learn about mistakes to avoid when addressing this issue. If no additional references exist, the subject is not suitable for Wikipedia. If you would like to continue working on the submission, click on the "Edit" tab at the top of the window. If you have not resolved the issues listed above, your draft will be declined again and potentially deleted. If you need extra help, please ask us a question at the AfC Help Desk or get live help from experienced editors. Please do not remove reviewer comments or this notice until the submission is accepted. Where to get help If you need help editing or submitting your draft, please ask us a question at the AfC Help Desk or get live help from experienced editors. These venues are only for help with editing and the submission process, not to get reviews. If you need feedback on your draft, or if the review is taking a lot of time, you can try asking for help on the talk page of a relevant WikiProject. Some WikiProjects are more active than others so a speedy reply is not guaranteed. How to improve a draft Wikipedia:Contributing to Wikipedia – a basic overview on how to edit Wikipedia. Help:Wikitext – how to use the markup Help:Referencing for beginners – how to include references Wikipedia:Article development – how to develop your article Wikipedia:Writing better articles – how to improve your article Wikipedia:Verifiability – make sure your article includes reliable third-party sources You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Add tags to your draft Editor resources Find sources: Google (books · news · scholar · free images · WP refs) · FENS · JSTOR · TWL Easy tools: Citation bot (help) | Advanced: Fix bare URLs Declined by Mgp28 24 days ago. Last edited 0 seconds ago. Reviewer: Inform author. Once you save your changes using the "Publish changes" button below, you will be able to resubmit your draft for review by pressing the "Resubmit" button that will appear here.

• Comment: To identify that a topic is sufficiently notable to need a Wikipedia article, we look for "significant coverage in reliable sources that are independent of the subject." Chang C. Liu, leader of the group that developed this method, is listed in as an author in all the references currently on this article. They are therefore not independent of the subject. I would like to see what authors outside this group are saying about the method, both to demonstrate that it is notable, and to make sure that we adopt a WP:Neutral point of view. Mgp28 (talk) 15:08, 24 July 2024 (UTC)

OrthoRep is a hypermutation system used for the directed evolution of proteins. It was developed by the group of Chang C. Liu at the University of California, Irvine. It is one of the methods used for in vivo continuous evolution, which aims to expand the depth and scale in the evolutionary search for highly efficient proteins compared to conventional directed evolution. The method is based on a natural plasmid system in Kluveromyces lactis, which was ported to Saccharomyces cerevisiae, creating an extrachromosomal orthogonal error-prone replication system in yeast.^[1]