Early 35 kDa protein

Early 35 kDa protein (AcMNPV)
P35 structure by Fisher et al. 1999[1]
Identifiers
Organism	Autographa californica nuclear polyhedrosis virus (AcMNPV)
Symbol	P35
Entrez	1403968
PDB	1P35
RefSeq (mRNA)	NC_001623.1
RefSeq (Prot)	NP_054165.1
UniProt	P08160
Other data
Chromosome	0: 0.12 - 0.12 Mb
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The Early 35 kDa protein, or P35 in short, is a baculoviral protein that inhibits apoptosis in the cells infected by the virus. Although baculoviruses infect only invertebrates in nature, ectopic expression of P35 in vertebrate animals and cells also results in inhibition of apoptosis, thus indicating a universal mechanism. P35 has been shown to be a caspase inhibitor with a very wide spectrum of activity both in regard to inhibited caspase types and to species in which the mechanism is conserved.