Ebola viral protein 24

eVP24
Identifiers
SymboleVP24
PfamPF06389
InterProIPR009433
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Ebola viral protein 24 (eVP24) is considered a multifunctional secondary matrix protein present in viral particles.[1] The broad roles eVP24 performs involve the formation of fully functional and infectious viral particles, promotion of filamentous nucleocapsid formation, mediation of host responses to infection, and suppression of the host innate immune system. It has been noted that eVP24 function can overlap with that of two other viral proteins; eVP40 matrix protein which functions in virus budding, and eVP35 which is also associated with immune suppression.[2][3]

  1. ^ Shabman RS, Gulcicek EE, Stone KL, Basler CF (November 2011). "The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import". The Journal of Infectious Diseases. 204 Suppl 3: S904-10. doi:10.1093/infdis/jir323. PMC 3189985. PMID 21987768.
  2. ^ Han Z, Boshra H, Sunyer JO, Zwiers SH, Paragas J, Harty RN (February 2003). "Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding". Journal of Virology. 77 (3): 1793–800. doi:10.1128/JVI.77.3.1793-1800.2003. PMC 140957. PMID 12525613.
  3. ^ Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, et al. (August 2014). "Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1". Cell Host & Microbe. 16 (2): 187–200. doi:10.1016/j.chom.2014.07.008. PMC 4188415. PMID 25121748.

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