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Edessa is the historical name of a city in Mesopotamia, now Şanlıurfa, Turkey.
Edessa may also refer to:
- Edessa (bug), a large genus of stink bugs
- Edessa, Greece
- County of Edessa, a crusader state
- Osroene, an ancient kingdom and province of the Roman Empire
- Bishopric of Edessa
- Edessa, birth name of Jarael, a character in Star Wars: Knights of the Old Republic (comics)