Back إرغوكالسيفيرول Arabic Эргакальцыферол Byelorussian Ergocalciferol Catalan Ergokalciferol Czech Ergocalcifferol Welsh Ergocalciferol German Εργοκαλσιφερόλη Greek Ergokalciferolo Esperanto Ergocalciferol Spanish Ergokaltziferol Basque
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| Clinical data | |
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| Trade names | Drisdol, Calcidol, others |
| Other names | viosterol |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a616042 |
| License data | |
| Routes of administration | By mouth, intramuscular |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.014 |
| Chemical and physical data | |
| Formula | C28H44O |
| Molar mass | 396.659 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 114 to 118 °C (237 to 244 °F) |
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Ergocalciferol, also known as vitamin D2 and nonspecifically calciferol, is a type of vitamin D found in food and used as a dietary supplement.[3] As a supplement it is used to prevent and treat vitamin D deficiency.[4] This includes vitamin D deficiency due to poor absorption by the intestines or liver disease.[5] It may also be used for low blood calcium due to hypoparathyroidism.[5] It is used by mouth or injection into a muscle.[4][5]
Excessive doses can result in increased urine production, high blood pressure, kidney stones, kidney failure, weakness, and constipation.[6] If high doses are taken for a long period of time, tissue calcification may occur.[5] Normal doses are safe in pregnancy.[7] It works by increasing the amount of calcium absorbed by the intestines and kidneys.[6] Food in which it is found include some mushrooms.[8]
Ergocalciferol was first described in 1936.[9] Ergocalciferol is available as a generic medication and over the counter.[6] In 2021, it was the 35th most commonly prescribed medication in the United States, with more than 17 million prescriptions.[10][11] Certain foods such as breakfast cereal and margarine have ergocalciferol added to them in some countries.[12][13] It is on the World Health Organization's List of Essential Medicines.[14]
- ^ "Summary Basis of Decision (SBD) for Rayaldee". Health Canada. 23 October 2014. Archived from the original on 31 May 2022. Retrieved 29 May 2022.
- ^ "Ergocalciferol Injection BP 300,000IU - Summary of Product Characteristics (SmPC)". (emc). 8 July 2020. Archived from the original on 19 January 2021. Retrieved 10 June 2022.
- ^ Coulston AM, Boushey C, Ferruzzi M (2013). Nutrition in the Prevention and Treatment of Disease. Academic Press. p. 818. ISBN 9780123918840. Archived from the original on 30 December 2016.
- ^ a b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 703–704. ISBN 9780857111562.
- ^ a b c d World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 498. hdl:10665/44053. ISBN 9789241547659.
- ^ a b c "Ergocalciferol". The American Society of Health-System Pharmacists. Archived from the original on 30 December 2016. Retrieved 8 December 2016.
- ^ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 227. ISBN 9781284057560.
- ^ "Office of Dietary Supplements - Vitamin D". ods.od.nih.gov. 11 February 2016. Archived from the original on 31 December 2016. Retrieved 30 December 2016.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 451. ISBN 9783527607495. Archived from the original on 30 December 2016.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Ergocalciferol - Drug Usage Statistics". ClinCalc. Archived from the original on 13 April 2020. Retrieved 14 January 2024.
- ^ Feral P, Hall L (2005). Dining with Friends: The Art of North American Vegan Cuisine. Friends of Animals/Nectar Bat Press. p. 160. ISBN 9780976915904.
- ^ Bennett B, Sammartano R (2012). The Complete Idiot's Guide to Vegan Living (Second ed.). Penguin. p. Chapter 15. ISBN 9781615642793. Archived from the original on 30 December 2016.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.