Back إيرغومترين Arabic Ergometrin German Εργομητρίνη Greek Ergometrino Esperanto Ergometrina Spanish ارگومترین Persian Ergometriini Finnish Ergométrine French Ergometrin Croatian Էրգոմետրին Armenian
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| Trade names | Ergometrine Maleate, Ergonovine Maleate, Ergotrate, Ergotrate Maleate, Ergostat, Syntometrine, others[1][2] |
| Other names | ergonovine; d-lysergic acid β-propanolamide; d-lysergic acid α-hydroxymethylethylamide |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Metabolism | Liver (partly CYP3A4) |
| Elimination half-life | 2-phase (10 min; 2 hrs) |
| Excretion | Biliary |
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| ECHA InfoCard | 100.000.441 |
| Chemical and physical data | |
| Formula | C19H23N3O2 |
| Molar mass | 325.412 g·mol−1 |
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Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth.[4][1] It can be used either by mouth, by injection into a muscle, or injection into a vein.[4] It begins working within 15 minutes when taken by mouth and is faster in onset when used by injection.[4] Effects last between 45 and 180 minutes.[4]
Common side effect include high blood pressure, vomiting, seizures, headache, and low blood pressure.[4] Other serious side effects include ergotism.[4] It was originally made from the rye ergot fungus but can also be made from lysergic acid.[5][6] Ergometrine is regulated because it can be used to make lysergic acid diethylamide (LSD).[7]
Ergometrine was discovered in 1932.[5] It is on the World Health Organization's List of Essential Medicines.[8][9]
- ^ a b Morton IK, Hall JM (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 113–. ISBN 978-0-7514-0499-9.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 397–. ISBN 978-3-88763-075-1.
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-15.
- ^ a b c d e f "Ergonovine Maleate". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-25. Retrieved 1 December 2015.
- ^ a b Ravina E (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1st ed.). Weinheim: Wiley-VCH. p. 245. ISBN 9783527326693. Archived from the original on 2015-12-26.
- ^ Sneader W (2005). Drug Discovery: a History (Rev. and updated ed.). Chichester: Wiley. p. 349. ISBN 9780471899792. Archived from the original on 2015-12-26.
- ^ King LA (2009). Forensic chemistry of substance misuse : a guide to drug control. Cambridge, UK: Royal Society of Chemistry. p. 190. ISBN 9780854041787. Archived from the original on 2015-12-26.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.