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| Fatty-Acyl-CoA Synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Ribbon 3D model of Yeast Fatty Acid Synthase.[1] | |||||||||
| Identifiers | |||||||||
| EC no. | 2.3.1.86 | ||||||||
| CAS no. | 9045-77-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Fatty-acyl-CoA synthase, or more commonly known as yeast fatty acid synthase (and not to be confused with long chain fatty acyl-CoA synthetase), is an enzyme complex responsible for fatty acid biosynthesis, and is of Type I Fatty Acid Synthesis (FAS). Yeast fatty acid synthase plays a pivotal role in fatty acid synthesis. It is a 2.6 MDa barrel shaped complex and is composed of two, unique multi-functional subunits: alpha and beta.[2] Together, the alpha and beta units are arranged in an α6β6 structure.[3][4] The catalytic activities of this enzyme complex involves a coordination system of enzymatic reactions between the alpha and beta subunits. The enzyme complex therefore consists of six functional centers for fatty acid synthesis.[3][5]
- ^ Xiong, Y.; Lomakin, I.B.; Steitz, T.A. (2007). "Structural Insights of Yeast Fatty Acid Synthase". Cell. 129. PDB: 319–332. doi:10.2210/pdb2pff/pdb.
- ^ Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W (May 2010). "Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy". Proc. Natl. Acad. Sci. U.S.A. 107 (20): 9164–9. Bibcode:2010PNAS..107.9164G. doi:10.1073/pnas.0913547107. PMC 2889056. PMID 20231485.
- ^ a b Singh N, Wakil SJ, Stoops JK (November 1985). "Yeast fatty acid synthase: structure to function relationship". Biochemistry. 24 (23): 6598–602. doi:10.1021/bi00344a044. PMID 3910094.
- ^ Stoops JK, Singh N, Wakil SJ (October 1990). "The yeast fatty acid synthase. Pathway for transfer of the acetyl group from coenzyme A to the Cys-SH of the condensation site". J. Biol. Chem. 265 (28): 16971–7. doi:10.1016/S0021-9258(17)44855-1. PMID 2211602.
- ^ Mohamed AH, Chirala SS, Mody NH, Huang WY, Wakil SJ (September 1988). "Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence". J. Biol. Chem. 263 (25): 12315–25. doi:10.1016/S0021-9258(18)37757-3. PMID 2900835.