Back فيبرونكتين جنيني Arabic Fibronektin#Fetales Fibronektin German 胎児性フィブロネクチン Japanese Fibronectin thai nhi Vietnamese
Fetal fibronectin (fFN) is a fibronectin protein produced by fetal cells. It is found at the interface of the chorion and the decidua (between the fetal sac and the uterine lining). Fetal fibronectin is found normally in vaginal fluid in early pregnancy prior to 22 weeks due to normal growth and development of tissues at the junction of the uterus and amniotic sac. It may also be found in vaginal fluid after 36 weeks as labor approaches. However, fFN should not be detected between 22 and 36 weeks.[1]
It can be thought of as an adhesive or "biological glue" that binds the fetal sac to the uterine lining.[2] It is the product of alternative splicing of the fibronectin gene and contains a oncofetal domain not present in adult fibronectin.[3]
- ^ Berghella V, Saccone G (July 2019). "Fetal fibronectin testing for reducing the risk of preterm birth". The Cochrane Database of Systematic Reviews. 7 (7): CD006843. doi:10.1002/14651858.CD006843.pub3. PMC 6663121. PMID 31356681.
- ^ "Fetal fibronectin test". Mayo Clinic. Retrieved 19 March 2016.
- ^ Patten J, Wang K (March 2021). "Fibronectin in development and wound healing". Advanced Drug Delivery Reviews. 170: 353–368 (357). doi:10.1016/j.addr.2020.09.005. PMID 32961203.