Fluprednidene acetate

Fluprednidene acetate
Clinical data
Trade names	Decoderm, others
Other names	[2-[(9R,17R)-9-Fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylidene-3-oxo-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical (cream)
ATC code	D07AB07 (WHO) D07XB03 (WHO) (combinations);
Identifiers
	IUPAC name 2-[(1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-2,15-dimethyl-13-methylidene-5-oxotetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate;
CAS Number	1255-35-2 ;
PubChem CID	9980241;
DrugBank	DB08970 ;
ChemSpider	8155833;
UNII	GE65DV564S;
KEGG	D07980;
ChEBI	CHEBI:135700;
CompTox Dashboard (EPA)	DTXSID0048719 ;
ECHA InfoCard	100.013.649
Chemical and physical data
Formula	C24H29FO6
Molar mass	432.488 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)OCC(=O)[C@]1(C(=C)C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)O;
	InChI InChI=1S/C24H29FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,17-19,28,30H,1,5-6,9,11-12H2,2-4H3/t17-,18-,19-,21-,22-,23-,24-/m0/s1; Key:DEFOZIFYUBUHHU-IYQKUMFPSA-N;
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Fluprednidene acetate (trade name Decoderm among others) is a moderately potent glucocorticoid used in form of a cream to treat skin inflammations such as atopic dermatitis and contact dermatitis.^[1]^[2]

^ Haberfeld H, ed. (2017). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Decoderm-Creme.
^ de Groot AC (February 2021). "Fluprednidene acetate". Monographs in Contact Allergy, Volume 3: Topical Drugs (First ed.). Boca Raton, FL: CRC Press. p. 355. ISBN 978-1-00-036786-7.