Fluvastatin

Fluvastatin
Clinical data
Trade names	Lescol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a694010
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth (capsules, tablets)
ATC code	C10AA04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	24–30%
Protein binding	>98%
Metabolism	Hepatic: CYP2C9 (75%), CYP3A4 (20%), CYP2C8 (5%)
Elimination half-life	1–3 hours (capsule), 9 hours (XR formulations)
Excretion	Faeces (95%), urine (5%)
Identifiers
	IUPAC name (3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid;
CAS Number	93957-54-1 ;
PubChem CID	446155;
IUPHAR/BPS	2951;
DrugBank	DB01095 ;
ChemSpider	393587 ;
UNII	4L066368AS;
KEGG	D07983 ;
ChEBI	CHEBI:38565 ;
ChEMBL	ChEMBL1078 ;
CompTox Dashboard (EPA)	DTXSID201020962 DTXSID2020636, DTXSID201020962 ;
ECHA InfoCard	100.224.327
Chemical and physical data
Formula	C24H26FNO4
Molar mass	411.473 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C[C@H](O)C[C@H](O)/C=C/c2c(c1ccccc1n2C(C)C)c3ccc(F)cc3;
	InChI InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 ; Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N ;
	(verify)

Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.

It was patented in 1982 and approved for medical use in 1994.^[4] It is on the World Health Organization's List of Essential Medicines.^[5]

^ Cite error: The named reference AC was invoked but never defined (see the help page).
^ ^a ^b ^c ^d ^e Neuvonen PJ, Backman JT, Niemi M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955. S2CID 11716425.
^ ^a ^b "Lescol, Lescol XR (fluvastatin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 18 March 2014.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.