Francis Thomas (1799–1876) was an American politician and Governor of Maryland.
Francis Thomas may also refer to:
- Francis A. Thomas (1826–1899), American physician and New York City politician
- Francis Wolferstan Thomas (1834–1900), Canadian banker and philanthropist
- Frank Thomas (bishop) (1930–1988), English prelate of the Roman Catholic Church
- Francis Thomas (politician) (1912–1977), Singaporean former politician and educator
- Francis Xavier Thomas (1906−1985), Australian Roman Catholic bishop