Francisco de Portugal, also known as Francis II of Portugal, 3rd Count of Vimioso (c. 1550 – 1582), was the eldest son and heir of the 2nd Count of Vimioso, Afonso de Portugal (Alphonse of Portugal).
He was one of the few high-ranking Portuguese nobles to support the claims of António, Prior of Crato, during the War of the Portuguese Succession (1580–1583).