Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily expressed[5]) is a protein that in humans is encoded by the GSDMD gene on chromosome 8.[6] It belongs to the gasdermin family which is conserved among vertebrates and comprises six members in humans, GSDMA, GSDMB, GSDMC, GSDMD, GSDME (DFNA5) and DFNB59 (Pejvakin). Members of the gasdermin family are expressed in a variety of cell types including epithelial cells and immune cells. GSDMA, GSDMB, GSDMC, GSDMD and GSDME have been suggested to act as tumour suppressors.[7]
- ^ a b c ENSG00000104518 GRCh38: Ensembl release 89: ENSG00000278718, ENSG00000104518 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022575 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Zou, Ju; Zheng, Yixiang; Huang, Yan; Tang, Daolin; Kang, Rui; Chen, Ruochan (2021). "The Versatile Gasdermin Family: Their Function and Roles in Diseases". Frontiers in Immunology. 12. doi:10.3389/fimmu.2021.751533. ISSN 1664-3224. PMC 8632255. PMID 34858408.
- ^ "Entrez Gene: Gasdermin D". Retrieved 2016-08-26.
- ^ "GSDMD gasdermin D [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.