Gallego is a Spanish surname. It is a regional name denoting someone from Galicia. Notable people with the surname include:
- Alain Bernat Gallego (born 1971), Andorran politician
- Américo Gallego, Argentine footballer
- Antonio Gallego Gallego, Spanish musicologist
- Blas Gallego (born 1941), Spanish artist
- Fernando Gallego (c. 1440–1507), Spanish painter
- Gerald and Charlene Gallego, a married couple who committed serial murders from 1978 to 1980
- Gina Gallego (born 1955), American actor
- José Gallego (footballer born 1923), Spanish footballer who played in England in the 1950s
- José Gallego (footballer born 1959), Spanish footballer with Athletic Bilbao
- Joseph Shalom Gallego (d. 1624), poet and cantor
- Luis Miguel Gallego (born 1970), Mexican singer
- Mike Gallego (born 1960), American baseball player and coach
- Pete Gallego, Texas politician
- Ricardo Gallego, Spanish footballer
- Ruben Gallego (born 1979), American politician
- Rubén Gallego (born 1968), Russian writer
- Soledad Gallego-Díaz (born 1950/1951), Spanish journalist