Gavril Istrati, or Istrate (died 1838), was a Moldavian boyar who mounted military resistance to the Filiki Eteria during the Greek War of Independence. Probably hailing from the yeomanry, he spent a while servicing the more powerful boyar Teodor "Frederic" Balș, and became a Paharnic in Botoșani city, near Moldavia's border with the Austrian Empire. An exponent of Romanian nationalism and a presumed ally of the Austrians, he participated in the boyar conspiracy which liberated Botoșani County, though his troops disbanded without making further gains; his effort matched a similar counter-rebellion in neighboring Wallachia.
Istrati was shunned by his former co-conspirator Ioan Sturdza, who took over as Prince of Moldavia after the clampdown on Eterism. He spent much of the following decade in Botoșani and Pașcani, and was at some point disfigured during a robbery attempt. Prince Mihail Sturdza reinstated the Istratis to high office, with Gavril carrying on as a Paharnic and Chief Justice in Iași County. He went into retirement in 1836, at the height of the Regulamentul Organic period, with his son Iancu replacing him as judge.
Gavril was also the father of politician and writer Nicolae Istrati, best known as the proponent of conservatism and Moldavian separatism during the United Principalities regime. Through him, the Istratis preserved their connections with Austria into the Crimean War and after. Another son, Manolachi (Meletie) Istrati, embraced a career in the Moldavian Orthodox Church, but assisted Nicolae in his intrigues. The brothers' agenda acquired a visual representation in monuments they erected at Rotopănești. Gavril's grandchildren also had careers in the justice system of the Romanian Kingdom, while a great-grandson, Edgar Istratty, was a noted opera singer.