General Powell frequently refers to Colin Powell (1937–2021), a US Army four-star general and US Secretary of State. It may also refer to:
- Henry Watson Powell (1733–1814), British Army general
- Herbert B. Powell (1903–1998), US Army general
- Kenneth R. Powell (1915–1987), US Air Force major general
- Roger Powell (general) (born 1949), Australian Army major general
- William G. Powell (1871–1955), U.S. Marine Corps major general
- William Henry Powell (soldier) (1825–1904), Union brigadier general in the American Civil War