Harrisburg (originally Harrisburgh, shortened to Harrisburg in 1892) is a community now located within the city of Houston, Texas.
The community is located east of downtown Houston, south of the Brays Bayou and Buffalo Bayou junction, and west of Brady's Island. It was founded before 1825 on the eastern stretches of the Buffalo Bayou in present-day Harris County, Texas, on land belonging to John Richardson Harris. In 1926, Harrisburg was annexed into the city of Houston. The original name of Harris County was Harrisburg (Harrisburgh) County until it was shortened after the demise of the City of Harrisburg. Historical markers at the John Richardson Harris site tell of General Santa Anna's razing the town as he chased Sam Houston and his retreating army just before they reached Lynch's ferry.