Henry Knox Thatcher | |
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| Born | May 26, 1806 Thomaston, Massachusetts, U.S. |
| Died | April 5, 1880 (aged 73) Winchester, Massachusetts, U.S. |
| Allegiance | United States of America |
| Service/ |  United States Navy |
| Years of service | 1823–1868 |
| Rank |  Rear admiral |
| Commands | Relief Decatur Constellation Colorado Western Gulf Squadron North Pacific Squadron |
| Battles/wars | American Civil War |
| Relations | Henry Knox (grandfather) Lucy Flucker Knox (grandmother) |
Henry Knox Thatcher (26 May 1806 – 5 April 1880) was a rear admiral in the United States Navy, who served during the American Civil War.