| Protein P (DNA polymerase / RNase H) | |||||||
|---|---|---|---|---|---|---|---|
 The genome organisation of HBV; the genes overlap. ORF P, in blue, encodes Hepatitis B virus DNA polymerase. | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | P | ||||||
| UniProt | P03156 | ||||||
| |||||||
| Protein P | |
|---|---|
| Identifiers | |
| Symbol | ? |
| InterPro | IPR037531 |
Hepatitis B virus DNA polymerase is a hepatitis B viral protein.[1][2] It is a DNA polymerase that can use either DNA or RNA templates and a ribonuclease H that cuts RNA in the duplex. Both functions are supplied by the reverse transcriptase (RT) domain.
- ^ Ono-Nita SK, Kato N, Shiratori Y, Masaki T, Lan KH, Carrilho FJ, Omata M (March 1999). "YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection". Hepatology. 29 (3): 939–45. doi:10.1002/hep.510290340. PMID 10051501.
- ^ Shaw T, Mok SS, Locarnini SA (November 1996). "Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir". Hepatology. 24 (5): 996–1002. doi:10.1002/hep.510240504. PMID 8903366.