E1 is one of two subunits of the envelope glycoprotein[1] found in the hepatitis C virus.[2][3] The other subunit is E2. This protein is a type 1 transmembrane protein with a highly glycosylated N-terminal ectodomain and a C-terminal hydrophobic anchor. After being synthesized the E1 glycoproteins associates with the E2 glycoprotein as a noncovalent heterodimer.[4]
- ^ Haddad, J.G.; Rouille, Y.; et al. (2017). "Identification of Novel Functions for Hepatitis C virus Envelope Glycoprotein E1 in Virus Entry and Assembly". Journal of Virology. 91 (11): e00048-17. doi:10.1128/JVI.00048-17. PMC 5375667. PMID 28179528.
- ^ Garcia JE, Puentes A, Súarez J, et al. (February 2002). "Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells". J. Hepatol. 36 (2): 254–62. doi:10.1016/S0168-8278(01)00262-8. PMID 11830338.
- ^ Bartosch B, Dubuisson J, Cosset FL (March 2003). "Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes". J. Exp. Med. 197 (5): 633–42. doi:10.1084/jem.20021756. PMC 2193821. PMID 12615904.
- ^ Lavie, M.; Goffard, A.; Dubuisson, J. In Chapter 4 HCV Glycoproteins: Assembly of a Functional E1-E2 heterodimer; Norfolk: UK, 2006; .