| Herpesvirus Glycoprotein B (PH-like 2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystallographic structure of glycoprotein B from herpes simplex virus type 1.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Glycoprot_B_PH2 | ||||||||
| Pfam | PF17417 | ||||||||
| InterPro | IPR038631 | ||||||||
| OPM superfamily | 109 | ||||||||
| OPM protein | 3nw8 | ||||||||
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| Herpesvirus Glycoprotein B (PH-like 1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glycoprot_B_PH1 | ||||||||
| Pfam | PF17416 | ||||||||
| InterPro | IPR035377 | ||||||||
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| Herpesvirus glycoprotein B ectodomain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glycoprotein_B | ||||||||
| Pfam | PF00606 | ||||||||
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Herpesvirus glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus (HSV). Herpesviruses have a lipid bilayer, called the envelope, which contains twelve surface glycoproteins. For infectivity to be attained, the double stranded DNA genome of HSV must enter the host cell through means of fusion of its envelope with the cellular membrane or via endocytosis. Other viral glycoproteins involved in the process of viral cell entry include gC, gB, gD, gH, and gL, but only gC, gB, gD, and gH are required for the fusion of the HSV's envelope with the cellular membrane. It can be noted that all herpesviruses have glycoproteins gB, gH, and gL.[2]
- ^ PDB: 3NW8; Stampfer SD, Lou H, Cohen GH, Eisenberg RJ, Heldwein EE (December 2010). "Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1". J. Virol. 84 (24): 12924–33. doi:10.1128/JVI.01750-10. PMC 3004323. PMID 20943984.
- ^ Pereira L, Ali M, Kousoulas K, Huo B, Banks T (September 1989). "Domain structure of herpes simplex virus 1 glycoprotein B: neutralizing epitopes map in regions of continuous and discontinuous residues". Virology. 172 (1): 11–24. doi:10.1016/0042-6822(89)90102-5. PMID 2475970.